Surugapyrroles A and B, two new N-hydroxypyrroles, as DPPH radical-scavengers from Streptomyces sp. USF-6280 strain

• Published in: Bioscience, biotechnology, and biochemistry Vol. 73; no. 1; pp. 230 - 232
• Main Authors: Sugiyama, Y.(Shizuoka Univ. (Japan). School of Food and Nutritional Sciences), Watanabe, K, Horita, A
• Format: Journal Article
• Language: English
• Published: Tokyo Japan Society for Bioscience, Biotechnology, and Agrochemistry 01.01.2009; Japan Society for Bioscience Biotechnology and Agrochemistry; Oxford University Press
• Subjects: AISLAMIENTO; Biological and medical sciences; Biphenyl Compounds; CELL CULTURE; COMPOSE HETEROCYCLIQUE; COMPUESTOS HETEROCICLICOS; CULTIVO DE CELULAS; CULTURE DE CELLULE; DPPH radical-scavenger; ESPECTROMETRIA DE MASAS; ESPECTROSCOPIA RMN; EXTRACCION; EXTRACTION; Free Radical Scavengers - chemistry; Free Radical Scavengers - isolation & purification; Fundamental and applied biological sciences. Psychology; HETEROCYCLIC COMPOUNDS; ISOLATION; ISOLEMENT; MASS SPECTROMETRY; Molecular Structure; N-hydroxypyrrole; NMR SPECTROSCOPY; Picrates; PURIFICACION; PURIFICATION; Pyrroles - chemistry; Pyrroles - isolation & purification; SPECTROMETRIE DE MASSE; SPECTROSCOPIE RMN; Spectrum Analysis; STREPTOMYCES; Streptomyces - chemistry; Streptomyces sp. USF-6280; surugapyrrole A; surugapyrrole B; ULTRAESTRUCTURA; ULTRASTRUCTURE; Actinomycetales; Streptomycetaceae; DPPH radical-scavenger; Streptomyces; Bacteria; surugapyrrole B; Actinomycetes; surugapyrrole A; Streptomyces sp. USF-6280; N-hydroxypyrrole
• ISSN: 0916-8451; 1347-6947
• DOI: 10.1271/bbb.80617

Two new N-hydroxypyrroles, surugapyrroles A and B, were isolated as DPPH radical-scavengers from a culture broth of Streptomyces sp. USF-6280 strain. The structures of the two compounds were elucidated by spectroscopic evidences and derivatization. Their DPPH (2,2-diphenyl-1-picrylhydrazyl) radical-scavenging activity was as high as that of butylhydroxytoluene (BHT): surugapyrrole A, ED 50 50.3 μM; surugapyrrole B, ED 50 75.8 μM.