DNA hydrogel delivery vehicle for light-triggered and synergistic cancer therapy

A DNA hydrogel is reported as a delivery vehicle for gold nanorods and doxorubicin. The two photothermal and chemo cancer agents were co-loaded using electrostatic and DNA binding interactions, respectively. Light-triggered and highly synergistic combination cancer therapy was demonstrated in cellul...

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Published inNanoscale Vol. 7; no. 21; pp. 9433 - 9437
Main Authors Song, Jaejung, Im, Kyuhyun, Hwang, Sekyu, Hur, Jaehyun, Nam, Jutaek, Ahn, G-One, Hwang, Sungwoo, Kim, Sungjee, Park, Nokyoung
Format Journal Article
LanguageEnglish
Published England 07.06.2015
Subjects
Animals
Antineoplastic Agents - administration & dosage
Binding
Cancer
Cell Line, Tumor
Deoxyribonucleic acid
DNA - chemistry
Doxorubicin - administration & dosage
Drug Carriers - chemistry
Gold - chemistry
Humans
Hydrogel, Polyethylene Glycol Dimethacrylate - chemistry
Hydrogels
Light
Mice
Nanorods
Nanostructure
Nanotubes - chemistry
Nanotubes - ultrastructure
Neoplasms - drug therapy
Static Electricity
Therapy
Vehicles
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Summary:A DNA hydrogel is reported as a delivery vehicle for gold nanorods and doxorubicin. The two photothermal and chemo cancer agents were co-loaded using electrostatic and DNA binding interactions, respectively. Light-triggered and highly synergistic combination cancer therapy was demonstrated in cellular and animal models.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:2040-3364
2040-3372
DOI:10.1039/c5nr00858a