Qualitative Analysis of Proteins in Two Snake Venoms, Gloydius Blomhoffii and Agkistrodon Acutus

Snake venom is a complex mixture of various pharmacologically active substances, such as small proteins, peptides, and organic and mineral components. This paper aims to identify and analyse the proteins in common venomous snakes, such as ( ) and ( ), in Korea. We used mass spectrometry, electrophor...

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Published inJournal of pharmacopuncture Vol. 25; no. 1; pp. 52 - 62
Main Authors Ha, Su-Jeong, Choi, Yeo-Ok, Kwag, Eun-Bin, Kim, Soo-Dam, Yoo, Hwa-Seung, Kang, In-Cheol, Park, So-Jung
Format Journal Article
LanguageEnglish
Published Korea (South) The Korean Pharmacopuncture Institute (KPI) 31.03.2022
Korean Pharmacopuncture Institute
대한약침학회
Subjects
agkistrodon acutus
gloydius blomhoffii
Original
proteomics
venom proteome
venomics
한의학
venom proteome
venomics
gloydius blomhoffii
proteomics
agkistrodon acutus
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Summary:Snake venom is a complex mixture of various pharmacologically active substances, such as small proteins, peptides, and organic and mineral components. This paper aims to identify and analyse the proteins in common venomous snakes, such as ( ) and ( ), in Korea. We used mass spectrometry, electrophoresis, N-terminal sequencing and in-gel digestion to analyse the proteins in these two snake venoms. We identified eight proteins in venom and four proteins in venom. The proteins detected in and venoms were phospholipase A2, snake venom metalloproteinase and cysteine-rich secretory protein. Snake C-type lectin (snaclec) was unique to venom. These data will contribute to the current knowledge of proteins present in the venoms of viper snakes and provide useful information for investigating their therapeutic potential.
Bibliography:ObjectType-Article-1
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These authors contributed equally to this work.
ISSN:2093-6966
2234-6856
DOI:10.3831/KPI.2022.25.1.52