Expression and Function of the HNK-1 Carbohydrate
Glycosylation is a major post-translational protein modification, especially for cell surface proteins, which play important roles in a variety of cellular functions, including recognition and adhesion. Among them, we have been interested in HNK-1 (human natural killer-1) carbohydrate, which is char...
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Published in | Journal of biochemistry (Tokyo) Vol. 143; no. 6; pp. 719 - 724 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
England
Japanese Biochemical Society
01.06.2008
Oxford University Press |
Subjects | |
Online Access | Get full text |
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Summary: | Glycosylation is a major post-translational protein modification, especially for cell surface proteins, which play important roles in a variety of cellular functions, including recognition and adhesion. Among them, we have been interested in HNK-1 (human natural killer-1) carbohydrate, which is characteristically expressed on a series of cell adhesion molecules in the nervous system. The HNK-1 carbohydrate has a unique structural feature, i.e. a sulfated glucuronic acid is attached to the non-reducing terminal of an N-acetyllactosamine residue (HSO3-3GlcAβ1-3Galβ1-4GlcNAc-). We have cloned and characterized the biosynthetic enzymes (two glucuronyltransferases and a sulfotransferase), and also obtained evidence that the HNK-1 carbohydrate is involved in synaptic plasticity and memory formation. In this review, we describe recent findings regarding the expression mechanism and functional roles of this carbohydrate. |
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Bibliography: | ArticleID:mvm221 istex:60E19476D58F14EEDC4DCD6B4A2E318ECE690CE0 ark:/67375/HXZ-3B7V8KWM-7 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 ObjectType-Review-3 content type line 23 ObjectType-Feature-3 ObjectType-Review-1 |
ISSN: | 0021-924X 1756-2651 |
DOI: | 10.1093/jb/mvm221 |