microRNAs in cardiac regeneration and cardiovascular disease

microRNAs （miRNAs） are a class of small non-coding RNAs, which have been shown important to a wide range of biological process by post-transcriptionally regulating the expression of protein-coding genes, miRNAs have been demonstrated essential to normal cardiac development and function. Recently, nu...

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Published inScience China. Life sciences Vol. 56; no. 10; pp. 907 - 913
Main Authors Wu, GengZe, Huang, Zhan-Peng, Wang, Da-Zhi
Format Journal Article
LanguageEnglish
Published Beijing Science China Press 01.10.2013
Springer Nature B.V
Subjects
Animals
Biomedical and Life Sciences
Gene Expression Regulation
Heart - physiology
Heart Diseases - genetics
Humans
Life Sciences
microRNA
MicroRNAs - genetics
miRNA
Myocardium - metabolism
Regeneration - genetics
Review
再生
小分子RNA
心脏发育
心脏疾病
心血管疾病
编码基因
cardiovascular disease
microRNA
cardiac regeneration
cardiac remodeling
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Summary:microRNAs （miRNAs） are a class of small non-coding RNAs, which have been shown important to a wide range of biological process by post-transcriptionally regulating the expression of protein-coding genes, miRNAs have been demonstrated essential to normal cardiac development and function. Recently, numerous studies indicate miRNAs are involved in cardiac regenera- tion and cardiac disease, including cardiac hypertrophy, myocardial infarction and cardiac arrhythmia. These observations suggest miRNAs play important roles in cardiology. In this review, we summarize the recent progress of studying miRNAs in cardiac regeneration and cardiac disease. We also discuss the diagnostic and therapeutic potential of miRNAs in heart disease.
Bibliography:microRNA, cardiac regeneration, cardiac remodeling, cardiovascular disease
11-5841/Q
microRNAs （miRNAs） are a class of small non-coding RNAs, which have been shown important to a wide range of biological process by post-transcriptionally regulating the expression of protein-coding genes, miRNAs have been demonstrated essential to normal cardiac development and function. Recently, numerous studies indicate miRNAs are involved in cardiac regenera- tion and cardiac disease, including cardiac hypertrophy, myocardial infarction and cardiac arrhythmia. These observations suggest miRNAs play important roles in cardiology. In this review, we summarize the recent progress of studying miRNAs in cardiac regeneration and cardiac disease. We also discuss the diagnostic and therapeutic potential of miRNAs in heart disease.
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ISSN:1674-7305
1869-1889
DOI:10.1007/s11427-013-4534-9