Mitochondrial quality control in the brain: The physiological and pathological roles
The human brain has high energetic expenses and consumes over 20% of total oxygen metabolism. Abnormal brain energy homeostasis leads to various brain diseases. Among multiple factors that contribute to these diseases, mitochondrial dysfunction is one of the most common causes. Maintenance of mitoch...
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Published in | Frontiers in neuroscience Vol. 16; p. 1075141 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Switzerland
Frontiers Research Foundation
12.12.2022
Frontiers Media S.A |
Subjects | |
Online Access | Get full text |
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Summary: | The human brain has high energetic expenses and consumes over 20% of total oxygen metabolism. Abnormal brain energy homeostasis leads to various brain diseases. Among multiple factors that contribute to these diseases, mitochondrial dysfunction is one of the most common causes. Maintenance of mitochondrial integrity and functionality is of pivotal importance to brain energy generation. Mitochondrial quality control (MQC), employing the coordination of multiple mechanisms, is evolved to overcome many mitochondrial defects. Thus, not surprisingly, aberrant mitochondrial quality control results in a wide range of brain disorders. Targeting MQC to preserve and restore mitochondrial function has emerged as a promising therapeutic strategy for the prevention and treatment of brain diseases. Here, we set out to summarize the current understanding of mitochondrial quality control in brain homeostasis. We also evaluate potential pharmaceutically and clinically relevant targets in MQC-associated brain disorders. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 Edited by: Jun Zhao, United States Food and Drug Administration, United States Reviewed by: Liming Wang, Hunan University, China; Kaige Yan, Southern University of Science and Technology, China This article was submitted to Translational Neuroscience, a section of the journal Frontiers in Neuroscience |
ISSN: | 1662-4548 1662-453X 1662-453X |
DOI: | 10.3389/fnins.2022.1075141 |