High Prevalence of Clarithromycin Resistance and cagA, vacA, iceA2, and babA2 Genotypes of Helicobacter pylori in Brazilian Children

We isolated 45 Helicobacter pylori strains from 217 child patients. Resistance to clarithromycin, metronidazole, amoxicillin, and tetracycline was detected in 27%, 13%, 4%, and 0% of strains, respectively. The A2143G mutation was the most prevalent (67%) among clarithromycin-resistant strains. In ad...

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Published inJournal of Clinical Microbiology Vol. 48; no. 11; pp. 4266 - 4268
Main Authors Garcia, Gabriella T, Aranda, Katia R.S, Gonçalves, Manoel E.P, Cardoso, Silvia R, Iriya, Kiyoshi, Silva, Neusa P, Scaletsky, Isabel C.A
Format Journal Article
LanguageEnglish
Published Washington, DC American Society for Microbiology 01.11.2010
American Society for Microbiology (ASM)
Subjects
Adhesins, Bacterial - genetics
Adolescent
Anti-Bacterial Agents - pharmacology
Antigens, Bacterial - genetics
Bacterial Proteins - genetics
Bacteriology
Biological and medical sciences
Brazil - epidemiology
Child
Child, Preschool
Clarithromycin - pharmacology
Drug Resistance, Bacterial
Female
Fundamental and applied biological sciences. Psychology
Genotype
Helicobacter Infections - epidemiology
Helicobacter Infections - microbiology
Helicobacter Infections - pathology
Helicobacter pylori
Helicobacter pylori - classification
Helicobacter pylori - drug effects
Helicobacter pylori - genetics
Helicobacter pylori - isolation & purification
Humans
Infant
Male
Microbiology
Miscellaneous
Prevalence
Severity of Illness Index
Virulence Factors - genetics
Brazil
Human
Clarithromycin
Prevalence
Spirillales
Spirillaceae
Genotype
Macrolide
Epidemiology
Resistance
Antibiotic
Helicobacter pylori
Bacteria
Protein synthesis inhibitor
Antibacterial agent
Child
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Summary:We isolated 45 Helicobacter pylori strains from 217 child patients. Resistance to clarithromycin, metronidazole, amoxicillin, and tetracycline was detected in 27%, 13%, 4%, and 0% of strains, respectively. The A2143G mutation was the most prevalent (67%) among clarithromycin-resistant strains. In addition, strain genotyping revealed a significant association between gastritis severity and the simultaneous presence of cagA, vacA s1m1, iceA2, and babA2 genes.
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ISSN:0095-1137
1098-660X
DOI:10.1128/JCM.01034-10