Variant brain-derived neurotrophic factor val66met polymorphism engages memory-associated systems to augment olfaction

The neurogenetic basis of variability in human olfactory function remains elusive. This study examined olfactory performance and resting-state functional neuroimaging results from healthy volunteers within the context of the brain-derived neurotrophic factor (BDNF) val66met polymorphism with the aim...

Full description

Saved in:
Bibliographic Details
Published inScientific reports Vol. 12; no. 1; p. 20007
Main Authors Chao, Yun-Ting, Hong, Tzu-Yi, Yang, Ching-Ju, Hsieh, Jen-Chuen
Format Journal Article
LanguageEnglish
Published England Nature Publishing Group 21.11.2022
Nature Publishing Group UK
Nature Portfolio
Subjects
Alleles
Brain research
Brain-derived neurotrophic factor
Brain-Derived Neurotrophic Factor - genetics
Females
Gene polymorphism
Genotype
Genotype & phenotype
Humans
Medical imaging
Memory
Neurogenesis
Neuroimaging
Odors
Olfaction
Olfactory discrimination
Otolaryngology
Polymorphism
Polymorphism, Genetic
Semantics
Smell - genetics
Online AccessGet full text

Cover

More Information
Summary:The neurogenetic basis of variability in human olfactory function remains elusive. This study examined olfactory performance and resting-state functional neuroimaging results from healthy volunteers within the context of the brain-derived neurotrophic factor (BDNF) val66met polymorphism with the aim of unraveling the genotype-associated intrinsic reorganization of the olfactory network. We found that the presence of the Met allele is associated with better olfactory identification and additional engagement of semantic memory system within the olfactory network, in an allele dosage-dependent manner. This suggests that the Met allele may promote adaptive neural reorganization to augment olfactory capacity.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-022-24365-5