Matsuda-DeFronzo insulin sensitivity index is a better predictor than HOMA-IR of hypertension in Japanese: the Tanno-Sobetsu study

• Published in: Journal of human hypertension Vol. 26; no. 5; pp. 325 - 333
• Main Authors: FURUGEN, M, SAITOH, S, OHNISHI, H, AKASAKA, H, MITSUMATA, K, CHIBA, M, FURUKAWA, T, MIYAZAKI, Y, SHIMAMOTO, K, MIURA, T
• Format: Journal Article
• Language: English
• Published: Basingstoke Nature Publishing Group 01.05.2012
• Subjects: Aged; Arterial hypertension. Arterial hypotension; Biological and medical sciences; Biomarkers - blood; Blood and lymphatic vessels; Blood Glucose - metabolism; Blood Pressure; Body Mass Index; Cardiology. Vascular system; Clinical manifestations. Epidemiology. Investigative techniques. Etiology; Cross-Sectional Studies; Fasting - blood; Female; Glucose Tolerance Test; Health aspects; Homeostasis; Humans; Hypertension; Hypertension - blood; Hypertension - epidemiology; Hypertension - physiopathology; Insulin; Insulin - blood; Insulin Resistance; Japan - epidemiology; Linear Models; Logistic Models; Longitudinal Studies; Male; Medical sciences; Middle Aged; Models, Biological; Multivariate Analysis; Odds Ratio; Predictive Value of Tests; Prognosis; Risk Assessment; Risk Factors; Time Factors; Triglycerides; Triglycerides - blood; Japan; Hypertension; HOMA-IR; Matsuda-DeFronzo insulin sensitivity index; Cardiovascular disease; Epidemiology; Insulin; Japanese; insulin resistance
• ISSN: 0950-9240; 1476-5527
• DOI: 10.1038/jhh.2011.23

Here we examined whether the Matsuda-DeFronzo insulin sensitivity index (ISI-M) is more efficient than the homeostasis model assessment of insulin resistance (HOMA-IR) for assessing risk of hypertension. Cross-sectional and longitudinal analyses were conducted using normotensive subjects who were selected among 1399 subjects in the Tanno-Sobetsu cohort. In the cross-sectional analysis (n=740), blood pressure (BP) level was correlated with HOMA-IR and with ISI-M, but correlation coefficients indicate a tighter correlation with ISI-M. Multiple linear regression analysis adjusted by age, sex, body mass index (BMI) and serum triglyceride level (TG) showed contribution of ISI-M and fasting plasma glucose, but not of HOMA-IR. In the longitudinal analysis (n=607), 241 subjects (39.7%) developed hypertension during a 10-year follow-up period, and multiple logistic regression indicated that age, TG, systolic BP and ISI-M, but not HOMA-IR, were associated with development of hypertension. In subjects <60 years old, odds ratio of new-onset hypertension was higher in the low ISI-M group (ISI-M, less than the median) than in the high ISI-M group for any tertile of BMI. In conclusion, ISI-M is a better predictor of hypertension than is HOMA-IR. Non-hepatic IR may be a determinant, which is independent of TG, BP level and BMI, of the development of hypertension.