Amination of Aryl Halides and Esters Using Intensified Continuous Flow Processing

Significant process intensification of the amination reactions of aryl halides and esters has been demonstrated using continuous flow processing. Using this technology traditionally difficult amination reactions have been performed safely at elevated temperatures. These reactions were successfully c...

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Bibliographic Details
Published inMolecules (Basel, Switzerland) Vol. 20; no. 10; pp. 17860 - 17871
Main Authors Kohl, Thomas M, Hornung, Christian H, Tsanaktsidis, John
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 25.09.2015
MDPI
Subjects
Amination
Ammonia
Batch processes
Chemistry
Chemistry Techniques, Synthetic
Chloride
continuous flow processing
Esters
flow chemistry
process intensification
Reactors
Spacetime
Temperature
continuous flow processing
process intensification
amination
flow chemistry
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Summary:Significant process intensification of the amination reactions of aryl halides and esters has been demonstrated using continuous flow processing. Using this technology traditionally difficult amination reactions have been performed safely at elevated temperatures. These reactions were successfully conducted on laboratory scale coil reactor modules with 1 mm internal diameter (ID) and on a preparatory scale tubular reactor with 6 mm ID containing static mixers.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1420-3049
1420-3049
DOI:10.3390/molecules201017860