The shape of things to come: structural insights into how prion proteins encipher heritable information

The prion hypothesis embodies the radical concept that prion proteins contain the necessary information for infectious replication within their shape, thus obviating the requirement for genomic material. Two elegant papers by Hoyt et al. and Manka et al. describing high-resolution structures of infe...

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Bibliographic Details
Published inNature communications Vol. 13; no. 1; pp. 4003 - 3
Main Author Telling, Glenn C
Format Journal Article
LanguageEnglish
Published England Nature Publishing Group 13.07.2022
Nature Publishing Group UK
Nature Portfolio
Subjects
Comment
Humans
Infections
Prion Diseases
Prion protein
Prion Proteins - genetics
Prions
Prions - metabolism
Proteins
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Summary:The prion hypothesis embodies the radical concept that prion proteins contain the necessary information for infectious replication within their shape, thus obviating the requirement for genomic material. Two elegant papers by Hoyt et al. and Manka et al. describing high-resolution structures of infectious prions bring us closer to answering the long-standing question of how different prion conformations produce heritably distinct diseases.
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ISSN:2041-1723
2041-1723
DOI:10.1038/s41467-022-31460-8