New Furanones from the Plant Endophytic Fungus Pestalotiopsis besseyi

• Published in: Molecules (Basel, Switzerland) Vol. 17; no. 12; pp. 14015 - 14021
• Main Authors: Liu, Haitao, Liu, Shuchun, Guo, Liangdong, Zhang, Yonggang, Cui, Langjun, Ding, Gang
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 27.11.2012; MDPI
• Subjects: Alternaria - drug effects; Anti-HIV Agents - pharmacology; Antifungal Agents - chemistry; Antifungal Agents - isolation & purification; Antifungal Agents - pharmacology; bioactivity; Cell Line; endophytes; Furans - chemistry; Furans - isolation & purification; Furans - pharmacology; Herbal medicine; HIV Infections - drug therapy; HIV-1 - drug effects; Humans; Magnetic Resonance Spectroscopy; Metabolites; Molecular Structure; Pathogens; pestalafuranones A– Pestalotiopsis besseyi; Plants - chemistry; Plants - drug effects; Plants - microbiology; Verticillium - drug effects; Xylariales - chemistry; Beijing China; China
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules171214015

Pestalafuranones A–E (compounds 1–5), five new 2(5H)-furanones, have been isolated from cultures of an isolate of Pestalotiopsis besseyi. The structures of these compounds were elucidated mainly by analysis of their NMR spectroscopic data and HRESIMS experiments. Pestalafuranones A–C (compounds 1–3) displayed weak inhibitory effects against HIV-1 replication in C8166 cells, whereas pestalafuranones D (4) and E (5) showed moderate antifungal activity against the plant pathogens Verticillium dahiae and Alternaria longipes.