High Throughput T Epitope Mapping and Vaccine Development

• Published in: BioMed research international Vol. 2010; no. 2010; pp. 1 - 12
• Main Authors: Li Pira, Giuseppina, Ivaldi, Federico, Moretti, Paolo, Manca, Fabrizio
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Puplishing Corporation 01.01.2010; Hindawi Publishing Corporation; John Wiley & Sons, Inc
• Subjects: Algorithms; Animals; Antigens; Automation; Epitope Mapping - methods; Epitopes, T-Lymphocyte; High-Throughput Screening Assays - methods; Humans; Immunology; Lymphocytes; Mice; Models, Immunological; Pathogens; Peptides; Proteins; Review; Vaccines; Workloads; Italy

Mapping of antigenic peptide sequences from proteins of relevant pathogens recognized by T helper (Th) and by cytolytic T lymphocytes (CTL) is crucial for vaccine development. In fact, mapping of T-cell epitopes provides useful information for the design of peptide-based vaccines and of peptide libr...