Temporospatial characterization of ventricular wall motion with real-time cardiac magnetic resonance imaging in health and disease

• Published in: Scientific reports Vol. 12; no. 1; p. 4070
• Main Authors: Li, Yu Y, Rashid, Shams, Craft, Jason, Cheng, Yang J, Schapiro, William, Gliganic, Kathleen, Yamashita, Ann-Marie, Grgas, Marie, Haag, Elizabeth, Cao, J Jane
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 08.03.2022; Nature Publishing Group UK; Nature Portfolio
• Subjects: Congestive heart failure; Coronary artery disease; Data acquisition; Heart Failure; Heart Ventricles; Humans; Magnetic resonance imaging; Magnetic Resonance Imaging - methods; Magnetic Resonance Imaging, Cine - methods; Periodicity; Reproducibility of Results; Retrospective Studies; Stroke Volume; Ventricle; Ventricular Function, Left
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-022-08094-3

Cardiac magnetic resonance imaging (MRI) has been largely dependent on retrospective cine for data acquisition. Real-time imaging, although inferior in image quality to retrospective cine, is more informative about motion dynamics. We herein developed a real-time cardiac MRI approach to temporospatial characterization of left ventricle (LV) and right ventricle (RV) wall motion. This approach provided two temporospatial indices, temporal periodicity and spatial coherence, for quantitative assessment of ventricular function. In a cardiac MRI study, we prospectively investigated temporospatial characterization in reference to standard volumetric measurements with retrospective cine. The temporospatial indices were found to be effective for evaluating the difference of ventricular performance between the healthy volunteers and the heart failure (HF) patients (LV temporal periodicity 0.24 ± 0.037 vs. 0.14 ± 0.021; RV temporal periodicity 0.18 ± 0.030 vs. 0.10 ± 0.014; LV spatial coherence 0.52 ± 0.039 vs. 0.38 ± 0.040; RV spatial coherence 0.50 ± 0.036 vs. 0.35 ± 0.035; all in arbitrary unit). The HF patients and healthy volunteers were well differentiated in the scatter plots of spatial coherence and temporal periodicity while they were mixed in those of end-systolic volume (ESV) and ejection fraction (EF) from volumetric measurements. This study demonstrated the potential of real-time cardiac MRI for intricate analysis of ventricular function beyond retrospective cine.