Analysis of Bordetella pertussis Agglutinin Titers during an Outbreak of Pertussis at a University in Japan

In 2007, a large outbreak of pertussis occurred at a university in Japan. Initially, a student, suffering from nocturnal cough and post-tussive vomiting for 3 weeks was diagnosed with pertussis. During the subsequent outbreak, 361 university students and staff members presented with a primary compla...

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Published inJapanese Journal of Infectious Diseases Vol. 63; no. 2; pp. 108 - 112
Main Authors Kamano, Hiroshi, Mori, Tomomi, Maeta, Hajime, Taminato, Tomohiko, Ishida, Toshihiko, Kishimoto, Nobuhito, Katami, Tomohiko, Sato, Makoto, Kamachi, Kazunari, Mochida, Yoshiyuki
Format Journal Article
LanguageEnglish
Published Japan National Institute of Infectious Diseases, Japanese Journal of Infectious Diseases Editorial Committee 31.03.2010
Subjects
Adolescent
Adult
Agglutinins - blood
Bordetella pertussis
Bordetella pertussis - immunology
Disease Outbreaks
Female
Humans
Incidence
Japan - epidemiology
Male
Middle Aged
Sensitivity and Specificity
Students
Universities
Whooping Cough - diagnosis
Whooping Cough - epidemiology
Whooping Cough - pathology
Young Adult
Japan
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Summary:In 2007, a large outbreak of pertussis occurred at a university in Japan. Initially, a student, suffering from nocturnal cough and post-tussive vomiting for 3 weeks was diagnosed with pertussis. During the subsequent outbreak, 361 university students and staff members presented with a primary complaint of a cough. In the present study, we analyzed bacterial agglutinin titers against two Bordetella pertussis strains, Yamaguchi (epidemic strain) and Tohama (vaccine strain), in 310 patients with a cough and evaluated its diagnostic accuracy for adolescent and adult pertussis. These serological analyses showed a significant difference (P<0.001) in the levels of Yamaguchi agglutinin titer, but not in those of Tohama agglutinin titer, between patient and healthy adult groups. Therefore, the bacterial agglutination assay against strain Yamaguchi may be a useful tool for diagnosis of adolescent and adult pertussis, especially in young adults, when an agglutinin titer cutoff value of ≥160x is used in combination with clinical symptoms and other clinical laboratory tests.
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ISSN:1344-6304
1884-2836
DOI:10.7883/yoken.63.108