Gastric cancer risk in achlorhydric patients. A long-term follow-up study

Achlorhydria, determined by the augmented histamine test, is the functional expression of the most severe atrophic gastritis and is followed by a 4- to 6-fold increased risk of gastric cancer, as we found 5 cancers in 114 patients after a mean observation period of 8.4 years. The cancers developed f...

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Bibliographic Details
Published inScandinavian journal of gastroenterology Vol. 21; no. 1; p. 16
Main Authors Svendsen, J H, Dahl, C, Svendsen, L B, Christiansen, P M
Format Journal Article
LanguageEnglish
Published England 01.01.1986
Subjects
Achlorhydria - complications
Adult
Aged
Denmark
Female
Follow-Up Studies
Humans
Male
Middle Aged
Risk
Stomach Neoplasms - epidemiology
Stomach Neoplasms - etiology
Time Factors
Denmark
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Summary:Achlorhydria, determined by the augmented histamine test, is the functional expression of the most severe atrophic gastritis and is followed by a 4- to 6-fold increased risk of gastric cancer, as we found 5 cancers in 114 patients after a mean observation period of 8.4 years. The cancers developed from 1 to 17 years after achlorhydria diagnosis--three cases after more than 9 years. The study showed no difference in gastric cancer risk between patients with and without pernicious anaemia. Spontaneous achlorhydria is the late result of atrophic gastritis, which should be regarded the premalignant condition. The development of gastric cancer from pharmacologically reduced acid secretion must be regarded as highly hypothetical, since this is not followed by atrophic gastritis.
ISSN:0036-5521
DOI:10.3109/00365528609034615