Development of an advanced synthetic route to macrosphelides and its application to the discovery of a more potent macrosphelide derivative
The discovery of a more cytotoxic macrosphelide derivative, including its total synthesis and bioassay are described. Application of the Koide protocol to a readily available propagylic alcohol allowed the rapid and practical synthesis of a macrosphelide A skeleton. This strategy enabled the success...
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Published in | Molecules (Basel, Switzerland) Vol. 19; no. 10; pp. 15572 - 15583 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Switzerland
MDPI AG
29.09.2014
MDPI |
Subjects | |
Online Access | Get full text |
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Summary: | The discovery of a more cytotoxic macrosphelide derivative, including its total synthesis and bioassay are described. Application of the Koide protocol to a readily available propagylic alcohol allowed the rapid and practical synthesis of a macrosphelide A skeleton. This strategy enabled the successful improvement of the cytotoxic activity of the macrosphelide derivative. |
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ISSN: | 1420-3049 1420-3049 |
DOI: | 10.3390/molecules191015572 |