Accessory proteins of the RAS-MAPK pathway: moving from the side line to the front line

Health and disease are directly related to the RTK-RAS-MAPK signalling cascade. After more than three decades of intensive research, understanding its spatiotemporal features is afflicted with major conceptual shortcomings. Here we consider how the compilation of a vast array of accessory proteins m...

Full description

Saved in:
Bibliographic Details
Published inCommunications biology Vol. 4; no. 1; p. 696
Main Authors Pudewell, Silke, Wittich, Christoph, Kazemein Jasemi, Neda S, Bazgir, Farhad, Ahmadian, Mohammad R
Format Journal Article
LanguageEnglish
Published England Nature Publishing Group 08.06.2021
Nature Publishing Group UK
Nature Portfolio
Subjects
Animals
Biology
Humans
MAP kinase
MAP Kinase Signaling System
Mitogen-Activated Protein Kinases - metabolism
Neoplasms - metabolism
Proteins
ras Proteins - metabolism
Signal Transduction
Online AccessGet full text

Cover

Abstract Health and disease are directly related to the RTK-RAS-MAPK signalling cascade. After more than three decades of intensive research, understanding its spatiotemporal features is afflicted with major conceptual shortcomings. Here we consider how the compilation of a vast array of accessory proteins may resolve some parts of the puzzles in this field, as they safeguard the strength, efficiency and specificity of signal transduction. Targeting such modulators, rather than the constituent components of the RTK-RAS-MAPK signalling cascade may attenuate rather than inhibit disease-relevant signalling pathways.
AbstractList Health and disease are directly related to the RTK-RAS-MAPK signalling cascade. After more than three decades of intensive research, understanding its spatiotemporal features is afflicted with major conceptual shortcomings. Here we consider how the compilation of a vast array of accessory proteins may resolve some parts of the puzzles in this field, as they safeguard the strength, efficiency and specificity of signal transduction. Targeting such modulators, rather than the constituent components of the RTK-RAS-MAPK signalling cascade may attenuate rather than inhibit disease-relevant signalling pathways. Pudewell et al. discuss and advance our understanding of accessory proteins, which are crucial for the RTK-RAS-MAPK signalling cascade. They consider the therapeutic potential of targeting such modulators as an alternative to targeting constituent components of the RTK-RAS-MAPK signalling cascade in the treatment of diseases such as cancer.
Pudewell et al. discuss and advance our understanding of accessory proteins, which are crucial for the RTK-RAS-MAPK signalling cascade. They consider the therapeutic potential of targeting such modulators as an alternative to targeting constituent components of the RTK-RAS-MAPK signalling cascade in the treatment of diseases such as cancer.
Abstract Health and disease are directly related to the RTK-RAS-MAPK signalling cascade. After more than three decades of intensive research, understanding its spatiotemporal features is afflicted with major conceptual shortcomings. Here we consider how the compilation of a vast array of accessory proteins may resolve some parts of the puzzles in this field, as they safeguard the strength, efficiency and specificity of signal transduction. Targeting such modulators, rather than the constituent components of the RTK-RAS-MAPK signalling cascade may attenuate rather than inhibit disease-relevant signalling pathways.
Health and disease are directly related to the RTK-RAS-MAPK signalling cascade. After more than three decades of intensive research, understanding its spatiotemporal features is afflicted with major conceptual shortcomings. Here we consider how the compilation of a vast array of accessory proteins may resolve some parts of the puzzles in this field, as they safeguard the strength, efficiency and specificity of signal transduction. Targeting such modulators, rather than the constituent components of the RTK-RAS-MAPK signalling cascade may attenuate rather than inhibit disease-relevant signalling pathways.
Health and disease are directly related to the RTK-RAS-MAPK signalling cascade. After more than three decades of intensive research, understanding its spatiotemporal features is afflicted with major conceptual shortcomings. Here we consider how the compilation of a vast array of accessory proteins may resolve some parts of the puzzles in this field, as they safeguard the strength, efficiency and specificity of signal transduction. Targeting such modulators, rather than the constituent components of the RTK-RAS-MAPK signalling cascade may attenuate rather than inhibit disease-relevant signalling pathways.Pudewell et al. discuss and advance our understanding of accessory proteins, which are crucial for the RTK-RAS-MAPK signalling cascade. They consider the therapeutic potential of targeting such modulators as an alternative to targeting constituent components of the RTK-RAS-MAPK signalling cascade in the treatment of diseases such as cancer.
ArticleNumber 696
Author Pudewell, Silke
Wittich, Christoph
Kazemein Jasemi, Neda S
Bazgir, Farhad
Ahmadian, Mohammad R
Author_xml – sequence: 1
  givenname: Silke
  surname: Pudewell
  fullname: Pudewell, Silke
  organization: Institute of Biochemistry and Molecular Biology II, Medical Faculty of the Heinrich-Heine University, Düsseldorf, Germany
– sequence: 2
  givenname: Christoph
  surname: Wittich
  fullname: Wittich, Christoph
  organization: Institute of Biochemistry and Molecular Biology II, Medical Faculty of the Heinrich-Heine University, Düsseldorf, Germany
– sequence: 3
  givenname: Neda S
  surname: Kazemein Jasemi
  fullname: Kazemein Jasemi, Neda S
  organization: Institute of Biochemistry and Molecular Biology II, Medical Faculty of the Heinrich-Heine University, Düsseldorf, Germany
– sequence: 4
  givenname: Farhad
  surname: Bazgir
  fullname: Bazgir, Farhad
  organization: Institute of Biochemistry and Molecular Biology II, Medical Faculty of the Heinrich-Heine University, Düsseldorf, Germany
– sequence: 5
  givenname: Mohammad R
  orcidid: 0000-0002-2034-8894
  surname: Ahmadian
  fullname: Ahmadian, Mohammad R
  email: reza.ahmadian@hhu.de
  organization: Institute of Biochemistry and Molecular Biology II, Medical Faculty of the Heinrich-Heine University, Düsseldorf, Germany. reza.ahmadian@hhu.de
BackLink https://www.ncbi.nlm.nih.gov/pubmed/34103645$$D View this record in MEDLINE/PubMed
BookMark eNpdkktv1DAQxy1URB_0C3BAkbhwCfgVx-aAtKp4VBSBeIij5djj3ayy9tbOFu23r5MtVcvB8mjmPz_N2P9TdBRiAIReEPyGYCbfZk4xZjWmZDpc1ewJOqFMlUBwevQgPkbnOa8xxkQpJRh_ho4ZLwzBmxP0Z2Et5BzTvtqmOEIfchV9Na6g-rH4WX9dfP9Sbc24-mv276pNvOnDsvIpbmZF7h1UQx-gGuOcKJUwzpnn6Kk3Q4bzu_sM_f744dfF5_rq26fLi8VVbbkSYy0Fk4obCx1zGAuPASR2TWNUazij3BFmKWUN8c4L2yrLwRnLLXakBQmOnaHLA9dFs9bb1G9M2utoej0nYlpqk8beDqC70kQt6RrqPO8KR3gAYjuvhJRtJwvr_YG13XUbcBbCmMzwCPq4EvqVXsYbLYlsmWAF8PoOkOL1DvKoN322MAwmQNxlTRumGtpSTor01X_SddylUJ5qUpV5WoonID2obIo5J_D3wxCsJxvogw10sYCebaCnppcP17hv-ffp7BZmS69t
CitedBy_id crossref_primary_10_3390_cancers15184654
crossref_primary_10_3389_fcell_2023_1199356
crossref_primary_10_46239_ejbcs_1365464
crossref_primary_10_1021_acs_jafc_2c03618
crossref_primary_10_1080_21541248_2022_2089001
crossref_primary_10_1016_j_bpj_2022_01_018
crossref_primary_10_1042_BCJ20220493
crossref_primary_10_1016_j_bpj_2022_05_030
crossref_primary_10_3390_cells10071831
crossref_primary_10_1016_j_cellsig_2024_111140
crossref_primary_10_3390_futurepharmacol2010003
crossref_primary_10_3389_fendo_2022_951331
crossref_primary_10_3390_cancers16050901
crossref_primary_10_3390_ijms23168842
crossref_primary_10_3390_curroncol29090512
crossref_primary_10_1002_cbdv_202300865
crossref_primary_10_1016_j_ejmg_2022_104675
crossref_primary_10_1038_s42003_021_02923_3
crossref_primary_10_3390_ijms25021331
crossref_primary_10_3390_cells12131780
crossref_primary_10_1038_s41392_022_01149_x
crossref_primary_10_1016_j_ejogrb_2022_08_007
crossref_primary_10_1016_j_heliyon_2023_e23114
crossref_primary_10_1016_j_steroids_2023_109295
crossref_primary_10_1002_arch_22054
crossref_primary_10_1016_j_heliyon_2023_e22080
crossref_primary_10_3390_biom11060895
crossref_primary_10_3390_ijms222212142
crossref_primary_10_1038_s41420_023_01674_w
crossref_primary_10_1016_j_critrevonc_2023_103928
Cites_doi 10.1038/nrm3979
10.1016/0896-6273(94)90223-2
10.1016/S1534-5807(01)00035-1
10.1101/gad.190876.112
10.1073/pnas.052138899
10.1002/humu.23767
10.1074/jbc.M116.767087
10.1042/CBI20090016
10.1126/science.aau5721
10.1016/j.phrs.2012.04.005
10.1128/MCB.17.7.4087
10.1021/acs.jmedchem.7b01520
10.2302/kjm.2013-0002-RE
10.1136/jcp.2010.075853
10.1038/emm.2016.58
10.1038/s41388-020-1336-y
10.1038/35046659
10.1177/1947601911407328
10.1074/jbc.M111.287599
10.1093/hmg/ddaa263
10.2147/CMAR.S181066
10.1101/cshperspect.a033746
10.1016/j.ccell.2017.12.014
10.1172/JCI34472
10.1038/s41591-018-0024-8
10.1002/stem.247
10.1210/er.2017-00232
10.1042/BST20170528
10.1101/cshperspect.a031831
10.1038/s41568-020-0256-z
10.1073/pnas.1902658116
10.1002/humu.22809
10.1016/j.biochi.2008.10.010
10.1073/pnas.0901590106
10.1126/scisignal.2002796
10.1016/S0092-8674(00)81766-3
10.1016/j.bbrc.2007.01.037
10.1038/43686
10.1016/S1534-5807(02)00364-7
10.1038/sj.onc.1202411
10.1038/emboj.2008.308
10.1186/s12964-018-0307-1
10.1091/mbc.e07-10-1053
10.1073/pnas.0407577101
10.1016/j.bcp.2004.04.024
10.1016/j.chembiol.2019.12.006
10.1002/path.4502
10.1186/1752-0509-1-27
10.1073/pnas.1720352115
10.1038/nature12796
10.1016/j.molcel.2006.03.027
10.1530/EJE-12-0718
10.1074/jbc.M209082200
10.1074/jbc.M507360200
10.1038/nrm2901
10.1038/315550a0
10.1038/nature19327
10.1016/S0092-8674(00)81688-8
10.1158/0008-5472.CAN-08-1117
10.1038/s41591-018-0023-9
10.1186/1478-811X-7-22
10.1038/s41573-020-0068-6
10.1158/0008-5472.CAN-18-2372
10.1007/s12551-018-0434-3
10.1128/MCB.20.19.7109-7120.2000
10.18632/oncotarget.5173
10.1158/0008-5472.CAN-07-1998
10.1038/nrm.2017.7
10.1128/MCB.22.9.3035-3045.2002
10.1016/S1097-2765(04)00050-4
10.1038/s41586-019-1730-1
10.1038/nm.3165
10.1126/stke.2001.110.pe40
10.1126/scisignal.aav0917
10.1002/embj.201385946
10.1016/j.celrep.2020.107909
10.1534/genetics.111.136911
10.1111/j.1742-4658.2009.06928.x
10.1038/srep24165
10.1073/pnas.0704514104
10.1158/0008-5472.CAN-17-3629
10.1111/febs.13113
10.1016/j.devcel.2009.01.009
10.1073/pnas.96.23.13259
10.1080/14728222.2017.1311325
10.12688/f1000research.11774.1
10.1038/ng.425
10.1182/blood-2015-06-653006
10.1093/hmg/ddz108
10.1126/science.286.5438.309
10.1038/cr.2011.161
10.1038/sj.onc.1209635
10.1074/jbc.C200606200
10.3390/jpm10020020
10.1016/j.apsb.2018.08.009
10.1016/j.bbrc.2009.03.040
10.1101/cshperspect.a031500
10.1128/MCB.00191-16
10.1074/jbc.M111.227694
10.1128/MCB.15.2.593
10.1073/pnas.1607298113
10.1038/sj.onc.1210394
10.1016/S0092-8674(00)80252-4
10.1074/jbc.M001862200
10.1128/MCB.18.7.3966
10.1136/jmedgenet-2016-104432
10.1074/jbc.M109.001537
10.1038/sj.onc.1210421
10.1016/j.ejmg.2015.08.005
10.1126/science.aad9964
10.1016/j.febslet.2009.05.007
10.1038/ncb1615
10.1080/10409238.2018.1431605
10.1016/j.cell.2017.06.009
10.1177/1947601911407323
10.1038/s41388-019-0883-6
10.1038/nrm1743
10.1074/jbc.M117.802793
10.1111/febs.15450
10.15252/embr.201439834
10.1016/j.cellsig.2007.10.002
10.1042/bj3510289
10.1038/s41467-019-10367-x
10.1016/S0079-6603(02)71047-7
10.1111/j.1749-6632.2010.05790.x
10.1073/pnas.0305894101
10.1002/ajmg.b.32648
10.1016/j.ymthe.2019.01.016
10.1074/jbc.M113.527655
ContentType Journal Article
Copyright The Author(s) 2021. corrected publication 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
The Author(s) 2021, corrected publication 2021
Copyright_xml – notice: The Author(s) 2021. corrected publication 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
– notice: The Author(s) 2021, corrected publication 2021
DBID CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
3V.
7XB
88I
8FE
8FH
8FK
ABUWG
AFKRA
AZQEC
BBNVY
BENPR
BHPHI
CCPQU
DWQXO
GNUQQ
HCIFZ
LK8
M2P
M7P
PIMPY
PQEST
PQQKQ
PQUKI
PRINS
Q9U
7X8
5PM
DOA
DOI 10.1038/s42003-021-02149-3
DatabaseName Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
CrossRef
ProQuest Central (Corporate)
ProQuest Central (purchase pre-March 2016)
Science Database (Alumni Edition)
ProQuest SciTech Collection
ProQuest Natural Science Collection
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest Central UK/Ireland
ProQuest Central Essentials
Biological Science Collection
AUTh Library subscriptions: ProQuest Central
ProQuest Natural Science Collection
ProQuest One Community College
ProQuest Central
ProQuest Central Student
SciTech Premium Collection (Proquest) (PQ_SDU_P3)
Biological Sciences
ProQuest Science Journals
Biological Science Database
Access via ProQuest (Open Access)
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
ProQuest Central Basic
MEDLINE - Academic
PubMed Central (Full Participant titles)
Directory of Open Access Journals
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
CrossRef
Publicly Available Content Database
ProQuest Science Journals (Alumni Edition)
ProQuest Central Student
ProQuest Biological Science Collection
ProQuest Central Basic
ProQuest Central Essentials
ProQuest Science Journals
ProQuest One Academic Eastern Edition
ProQuest Central (Alumni Edition)
SciTech Premium Collection
ProQuest One Community College
ProQuest Natural Science Collection
Biological Science Database
ProQuest SciTech Collection
ProQuest Central China
ProQuest Central
ProQuest One Academic UKI Edition
Natural Science Collection
ProQuest Central Korea
Biological Science Collection
ProQuest One Academic
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList

CrossRef
MEDLINE
Publicly Available Content Database
Database_xml – sequence: 1
  dbid: DOA
  name: Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 2
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 3
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 4
  dbid: BENPR
  name: AUTh Library subscriptions: ProQuest Central
  url: https://www.proquest.com/central
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Biology
EISSN 2399-3642
EndPage 696
ExternalDocumentID oai_doaj_org_article_b0d12c1b52df4beda6fee1cbf96887b8
10_1038_s42003_021_02149_3
34103645
Genre Research Support, Non-U.S. Gov't
Journal Article
Review
GroupedDBID 0R~
53G
88I
AAJSJ
ABDBF
ABUWG
ACGFS
ACSMW
ADBBV
AFKRA
AJTQC
ALMA_UNASSIGNED_HOLDINGS
AOIJS
AZQEC
BBNVY
BCNDV
BENPR
BHPHI
C6C
CCPQU
CGR
CUY
CVF
DWQXO
EBLON
EBS
ECM
EIF
GNUQQ
GROUPED_DOAJ
HCIFZ
HYE
M2P
M7P
M~E
NAO
NPM
O9-
OK1
PGMZT
PIMPY
RNT
RPM
SNYQT
AAYXX
CITATION
3V.
7XB
8FE
8FH
8FK
LK8
PQEST
PQQKQ
PQUKI
PRINS
Q9U
7X8
5PM
AAADF
AFGXO
ID FETCH-LOGICAL-c496t-863894aceb3d006f0ee80d55a97a4324d13c22351fdf6c79c4edac4c0d17e8ed3
IEDL.DBID RPM
ISSN 2399-3642
IngestDate Thu Jul 04 20:54:54 EDT 2024
Tue Sep 17 21:28:07 EDT 2024
Tue Aug 27 04:39:47 EDT 2024
Fri Sep 13 08:46:15 EDT 2024
Fri Aug 23 00:56:08 EDT 2024
Sat Sep 28 08:22:22 EDT 2024
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 1
Language English
License Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c496t-863894aceb3d006f0ee80d55a97a4324d13c22351fdf6c79c4edac4c0d17e8ed3
Notes ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ORCID 0000-0002-2034-8894
OpenAccessLink https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8187363/
PMID 34103645
PQID 2538877203
PQPubID 4669726
PageCount 1
ParticipantIDs doaj_primary_oai_doaj_org_article_b0d12c1b52df4beda6fee1cbf96887b8
pubmedcentral_primary_oai_pubmedcentral_nih_gov_8187363
proquest_miscellaneous_2539527241
proquest_journals_2538877203
crossref_primary_10_1038_s42003_021_02149_3
pubmed_primary_34103645
PublicationCentury 2000
PublicationDate 2021-06-08
PublicationDateYYYYMMDD 2021-06-08
PublicationDate_xml – month: 06
  year: 2021
  text: 2021-06-08
  day: 08
PublicationDecade 2020
PublicationPlace England
PublicationPlace_xml – name: England
– name: London
PublicationTitle Communications biology
PublicationTitleAlternate Commun Biol
PublicationYear 2021
Publisher Nature Publishing Group
Nature Publishing Group UK
Nature Portfolio
Publisher_xml – name: Nature Publishing Group
– name: Nature Publishing Group UK
– name: Nature Portfolio
References A Wong (2149_CR29) 2002; 99
JIS MacDonald (2149_CR21) 2000; 275
C Elly (2149_CR28) 1999; 18
T Tian (2149_CR15) 2007; 9
N Gotoh (2149_CR40) 2004; 101
PY Chen (2149_CR39) 2009; 382
IB Stowe (2149_CR45) 2012; 26
JM Ostrem (2149_CR116) 2013; 503
S An (2149_CR52) 2015; 282
MM McKay (2149_CR1) 2007; 26
SL Harmer (2149_CR31) 1997; 17
M Tartaglia (2149_CR4) 2010; 1214
2149_CR124
2149_CR67
AJ Bardwell (2149_CR127) 2017; 292
2149_CR68
S Yao (2149_CR62) 2015; 236
SQ Zhang (2149_CR35) 2004; 13
LA Quilliam (2149_CR41) 2002; 71
CAP Joazeiro (2149_CR25) 1999; 286
YM Lee (2149_CR98) 2016; 48
W Kolch (2149_CR72) 2005; 6
BN Kholodenko (2149_CR8) 2010; 11
S Nakhaei-Rad (2149_CR3) 2018; 53
2149_CR117
I Bañón-Rodríguez (2149_CR84) 2014; 33
ET Keller (2149_CR81) 2004; 68
M Tajan (2149_CR103) 2018; 39
YH Lin (2149_CR17) 2017; 292
2149_CR113
2149_CR114
IC Morrow (2149_CR19) 2002; 277
D Kovalenko (2149_CR78) 2003; 278
P Dai (2149_CR60) 2006; 281
LC Young (2149_CR56) 2018; 115
RM Stephens (2149_CR30) 1994; 3
M Therrien (2149_CR90) 1998; 95
PD Stevens (2149_CR64) 2018; 78
S Guey (2149_CR110) 2017; 54
A Nguyen (2149_CR96) 2002; 22
D Matallanas (2149_CR65) 2011; 2
M Zhao (2149_CR133) 2019; 9
2149_CR102
M Zeng (2149_CR121) 2020; 27
SF Banani (2149_CR12) 2017; 18
2149_CR42
S Nada (2149_CR77) 2009; 28
H Lavoie (2149_CR2) 2015; 16
T Vomastek (2149_CR86) 2004; 101
2149_CR109
2149_CR49
M Murohashi (2149_CR34) 2010; 28
NS Dhawan (2149_CR128) 2016; 537
KL Inder (2149_CR55) 2009; 284
E Formstecher (2149_CR74) 2001; 1
IB del Río (2149_CR58) 2019; 116
F Sheikh (2149_CR88) 2008; 118
K Yeung (2149_CR80) 1999; 401
BK Neilsen (2149_CR129) 2017; 21
M Motta (2149_CR107) 2019; 40
Y Cui (2149_CR48) 2019; 38
CD White (2149_CR95) 2009; 583
S Khan (2149_CR119) 2020; 39
M Therrien (2149_CR91) 1999; 96
MF Brizzi (2149_CR27) 1996; 13
AS Dhillon (2149_CR5) 2007; 26
A Sanjay (2149_CR26) 2001; 2001
AC Mackinnon (2149_CR92) 2011; 64
2149_CR59
Z Zhang (2149_CR123) 2018; 10
W Biernat (2149_CR22) 2005; 43
S Kazeminasab (2149_CR111) 2018; 177
AR Moore (2149_CR115) 2020; 19
F Haghighi (2149_CR44) 2018; 16
P Rodriguez-Viciana (2149_CR57) 2006; 22
Z Zheng (2149_CR61) 2019; 27
T Dunzendorfer-Matt (2149_CR46) 2016; 113
S Rezaei Adariani (2149_CR66) 2018; 46
R Jagadeeswaran (2149_CR93) 2008; 68
MM McKay (2149_CR82) 2009; 106
T Yoshida (2149_CR94) 2006; 25
I Wortzel (2149_CR70) 2011; 2
DA Ruess (2149_CR132) 2018; 24
DK Simanshu (2149_CR43) 2017; 170
M Amaddii (2149_CR89) 2012; 287
KS Ravichandran (2149_CR23) 1995; 15
X Su (2149_CR13) 2016; 352
S Ivakhno (2149_CR16) 2007; 1
G Prelich (2149_CR122) 2012; 190
H Kouhara (2149_CR33) 1997; 89
YR Hadari (2149_CR36) 1998; 18
Y Ren (2149_CR79) 2007; 354
N Vasan (2149_CR118) 2019; 575
R Roskoski (2149_CR69) 2012; 66
S Mainardi (2149_CR131) 2018; 24
T Hunter (2149_CR14) 2000; 100
J Xie (2149_CR130) 2017; 60
O Blaževitš (2149_CR10) 2016; 6
AC Hedman (2149_CR85) 2015; 16
V Cordeddu (2149_CR108) 2009; 41
M Tajan (2149_CR38) 2015; 58
S Kaduwal (2149_CR97) 2015; 6
M Dance (2149_CR37) 2008; 20
H Brems (2149_CR105) 2013; 62
H Gu (2149_CR32) 2000; 20
DE McNulty (2149_CR83) 2011; 286
2149_CR87
M Sanclemente (2149_CR120) 2018; 33
P Castel (2149_CR6) 2020; 20
S Martinelli (2149_CR104) 2015; 36
N Zhang (2149_CR75) 2009; 34
AM Tari (2149_CR125) 2007; 31
W Yan (2149_CR106) 2020; 32
L Belanis (2149_CR53) 2008; 19
E Siljamäki (2149_CR47) 2016; 36
M Jaiswal (2149_CR51) 2014; 289
H Vaidyanathan (2149_CR73) 2007; 104
W Kolch (2149_CR71) 2000; 351
FU Wöhrle (2149_CR24) 2009; 7
2149_CR134
P Pamonsinlapatham (2149_CR50) 2009; 91
KL Jameson (2149_CR126) 2013; 19
WYC Huang (2149_CR20) 2019; 363
2149_CR99
R Shalom-Feuerstein (2149_CR54) 2008; 68
E Shtivelman (2149_CR101) 1985; 315
Y Liang (2149_CR112) 2018; 10
2149_CR9
T Jin (2149_CR18) 2012; 22
S Gu (2149_CR100) 2016; 127
2149_CR7
J Omerovic (2149_CR11) 2009; 276
D Teis (2149_CR76) 2002; 3
MC Wilkes (2149_CR63) 2009; 16
References_xml – volume: 16
  start-page: 281
  year: 2015
  ident: 2149_CR2
  publication-title: Nat. Rev. Mol. Cell Biol.
  doi: 10.1038/nrm3979
  contributor:
    fullname: H Lavoie
– volume: 3
  start-page: 691
  year: 1994
  ident: 2149_CR30
  publication-title: Neuron
  doi: 10.1016/0896-6273(94)90223-2
  contributor:
    fullname: RM Stephens
– volume: 1
  start-page: 239
  year: 2001
  ident: 2149_CR74
  publication-title: Dev. Cell
  doi: 10.1016/S1534-5807(01)00035-1
  contributor:
    fullname: E Formstecher
– volume: 26
  start-page: 1421
  year: 2012
  ident: 2149_CR45
  publication-title: Genes Dev.
  doi: 10.1101/gad.190876.112
  contributor:
    fullname: IB Stowe
– volume: 99
  start-page: 6684
  year: 2002
  ident: 2149_CR29
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.052138899
  contributor:
    fullname: A Wong
– volume: 13
  start-page: 2067
  year: 1996
  ident: 2149_CR27
  publication-title: Oncogene
  contributor:
    fullname: MF Brizzi
– volume: 40
  start-page: 23767
  year: 2019
  ident: 2149_CR107
  publication-title: Hum. Mutat.
  doi: 10.1002/humu.23767
  contributor:
    fullname: M Motta
– volume: 292
  start-page: 8750
  year: 2017
  ident: 2149_CR127
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M116.767087
  contributor:
    fullname: AJ Bardwell
– volume: 34
  start-page: 41
  year: 2009
  ident: 2149_CR75
  publication-title: Cell Biol. Int.
  doi: 10.1042/CBI20090016
  contributor:
    fullname: N Zhang
– volume: 363
  start-page: 1098
  year: 2019
  ident: 2149_CR20
  publication-title: Science
  doi: 10.1126/science.aau5721
  contributor:
    fullname: WYC Huang
– volume: 66
  start-page: 105
  year: 2012
  ident: 2149_CR69
  publication-title: Pharmacol. Res.
  doi: 10.1016/j.phrs.2012.04.005
  contributor:
    fullname: R Roskoski
– volume: 17
  start-page: 4087
  year: 1997
  ident: 2149_CR31
  publication-title: Mol. Cell. Biol.
  doi: 10.1128/MCB.17.7.4087
  contributor:
    fullname: SL Harmer
– volume: 60
  start-page: 10205
  year: 2017
  ident: 2149_CR130
  publication-title: J. Med. Chem.
  doi: 10.1021/acs.jmedchem.7b01520
  contributor:
    fullname: J Xie
– volume: 62
  start-page: 107
  year: 2013
  ident: 2149_CR105
  publication-title: Keio J. Med.
  doi: 10.2302/kjm.2013-0002-RE
  contributor:
    fullname: H Brems
– volume: 64
  start-page: 16
  year: 2011
  ident: 2149_CR92
  publication-title: J. Clin. Pathol.
  doi: 10.1136/jcp.2010.075853
  contributor:
    fullname: AC Mackinnon
– volume: 48
  year: 2016
  ident: 2149_CR98
  publication-title: Exp. Mol. Med.
  doi: 10.1038/emm.2016.58
  contributor:
    fullname: YM Lee
– volume: 39
  start-page: 4909
  year: 2020
  ident: 2149_CR119
  publication-title: Oncogene
  doi: 10.1038/s41388-020-1336-y
  contributor:
    fullname: S Khan
– ident: 2149_CR87
  doi: 10.1038/35046659
– volume: 2
  start-page: 195
  year: 2011
  ident: 2149_CR70
  publication-title: Genes Cancer
  doi: 10.1177/1947601911407328
  contributor:
    fullname: I Wortzel
– volume: 287
  start-page: 7265
  year: 2012
  ident: 2149_CR89
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M111.287599
  contributor:
    fullname: M Amaddii
– ident: 2149_CR49
  doi: 10.1093/hmg/ddaa263
– volume: 10
  start-page: 6445
  year: 2018
  ident: 2149_CR123
  publication-title: Cancer Manag. Res.
  doi: 10.2147/CMAR.S181066
  contributor:
    fullname: Z Zhang
– ident: 2149_CR67
  doi: 10.1101/cshperspect.a033746
– volume: 33
  start-page: 217
  year: 2018
  ident: 2149_CR120
  publication-title: Cancer Cell
  doi: 10.1016/j.ccell.2017.12.014
  contributor:
    fullname: M Sanclemente
– volume: 118
  start-page: 3870
  year: 2008
  ident: 2149_CR88
  publication-title: J. Clin. Invest.
  doi: 10.1172/JCI34472
  contributor:
    fullname: F Sheikh
– volume: 24
  start-page: 954
  year: 2018
  ident: 2149_CR132
  publication-title: Nat. Med.
  doi: 10.1038/s41591-018-0024-8
  contributor:
    fullname: DA Ruess
– volume: 28
  start-page: 113
  year: 2010
  ident: 2149_CR34
  publication-title: Stem Cells
  doi: 10.1002/stem.247
  contributor:
    fullname: M Murohashi
– volume: 39
  start-page: 676
  year: 2018
  ident: 2149_CR103
  publication-title: Endocr. Rev.
  doi: 10.1210/er.2017-00232
  contributor:
    fullname: M Tajan
– volume: 46
  start-page: 1393
  year: 2018
  ident: 2149_CR66
  publication-title: Biochem. Soc. Trans.
  doi: 10.1042/BST20170528
  contributor:
    fullname: S Rezaei Adariani
– ident: 2149_CR9
  doi: 10.1101/cshperspect.a031831
– volume: 20
  start-page: 383
  year: 2020
  ident: 2149_CR6
  publication-title: Nat. Rev. Cancer
  doi: 10.1038/s41568-020-0256-z
  contributor:
    fullname: P Castel
– volume: 116
  start-page: 13330
  year: 2019
  ident: 2149_CR58
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1902658116
  contributor:
    fullname: IB del Río
– volume: 36
  start-page: 787
  year: 2015
  ident: 2149_CR104
  publication-title: Hum. Mutat.
  doi: 10.1002/humu.22809
  contributor:
    fullname: S Martinelli
– volume: 91
  start-page: 320
  year: 2009
  ident: 2149_CR50
  publication-title: Biochimie
  doi: 10.1016/j.biochi.2008.10.010
  contributor:
    fullname: P Pamonsinlapatham
– volume: 106
  start-page: 11022
  year: 2009
  ident: 2149_CR82
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.0901590106
  contributor:
    fullname: MM McKay
– ident: 2149_CR102
  doi: 10.1126/scisignal.2002796
– volume: 95
  start-page: 343
  year: 1998
  ident: 2149_CR90
  publication-title: Cell
  doi: 10.1016/S0092-8674(00)81766-3
  contributor:
    fullname: M Therrien
– volume: 354
  start-page: 741
  year: 2007
  ident: 2149_CR79
  publication-title: Biochem. Biophys. Res. Commun.
  doi: 10.1016/j.bbrc.2007.01.037
  contributor:
    fullname: Y Ren
– volume: 401
  start-page: 173
  year: 1999
  ident: 2149_CR80
  publication-title: Nature
  doi: 10.1038/43686
  contributor:
    fullname: K Yeung
– volume: 3
  start-page: 803
  year: 2002
  ident: 2149_CR76
  publication-title: Dev. Cell
  doi: 10.1016/S1534-5807(02)00364-7
  contributor:
    fullname: D Teis
– volume: 18
  start-page: 1147
  year: 1999
  ident: 2149_CR28
  publication-title: Oncogene
  doi: 10.1038/sj.onc.1202411
  contributor:
    fullname: C Elly
– volume: 28
  start-page: 477
  year: 2009
  ident: 2149_CR77
  publication-title: EMBO J.
  doi: 10.1038/emboj.2008.308
  contributor:
    fullname: S Nada
– volume: 16
  year: 2018
  ident: 2149_CR44
  publication-title: Cell Commun. Signal.
  doi: 10.1186/s12964-018-0307-1
  contributor:
    fullname: F Haghighi
– volume: 19
  start-page: 1404
  year: 2008
  ident: 2149_CR53
  publication-title: Mol. Biol. Cell
  doi: 10.1091/mbc.e07-10-1053
  contributor:
    fullname: L Belanis
– volume: 101
  start-page: 17144
  year: 2004
  ident: 2149_CR40
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.0407577101
  contributor:
    fullname: N Gotoh
– volume: 68
  start-page: 1049
  year: 2004
  ident: 2149_CR81
  publication-title: Biochem. Pharmacol.
  doi: 10.1016/j.bcp.2004.04.024
  contributor:
    fullname: ET Keller
– volume: 27
  start-page: 19
  year: 2020
  ident: 2149_CR121
  publication-title: Cell Chem. Biol.
  doi: 10.1016/j.chembiol.2019.12.006
  contributor:
    fullname: M Zeng
– volume: 236
  start-page: 65
  year: 2015
  ident: 2149_CR62
  publication-title: J. Pathol.
  doi: 10.1002/path.4502
  contributor:
    fullname: S Yao
– volume: 1
  start-page: 1
  year: 2007
  ident: 2149_CR16
  publication-title: BMC Syst. Biol.
  doi: 10.1186/1752-0509-1-27
  contributor:
    fullname: S Ivakhno
– volume: 115
  start-page: E10576
  year: 2018
  ident: 2149_CR56
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1720352115
  contributor:
    fullname: LC Young
– volume: 503
  start-page: 548
  year: 2013
  ident: 2149_CR116
  publication-title: Nature
  doi: 10.1038/nature12796
  contributor:
    fullname: JM Ostrem
– volume: 22
  start-page: 217
  year: 2006
  ident: 2149_CR57
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2006.03.027
  contributor:
    fullname: P Rodriguez-Viciana
– ident: 2149_CR114
  doi: 10.1530/EJE-12-0718
– volume: 277
  start-page: 48834
  year: 2002
  ident: 2149_CR19
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M209082200
  contributor:
    fullname: IC Morrow
– volume: 281
  start-page: 927
  year: 2006
  ident: 2149_CR60
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M507360200
  contributor:
    fullname: P Dai
– volume: 11
  start-page: 414
  year: 2010
  ident: 2149_CR8
  publication-title: Nat. Rev. Mol. Cell Biol.
  doi: 10.1038/nrm2901
  contributor:
    fullname: BN Kholodenko
– volume: 315
  start-page: 550
  year: 1985
  ident: 2149_CR101
  publication-title: Nature
  doi: 10.1038/315550a0
  contributor:
    fullname: E Shtivelman
– volume: 537
  start-page: 112
  year: 2016
  ident: 2149_CR128
  publication-title: Nature
  doi: 10.1038/nature19327
  contributor:
    fullname: NS Dhawan
– volume: 100
  start-page: 113
  year: 2000
  ident: 2149_CR14
  publication-title: Cell
  doi: 10.1016/S0092-8674(00)81688-8
  contributor:
    fullname: T Hunter
– volume: 68
  start-page: 6608
  year: 2008
  ident: 2149_CR54
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-08-1117
  contributor:
    fullname: R Shalom-Feuerstein
– volume: 24
  start-page: 961
  year: 2018
  ident: 2149_CR131
  publication-title: Nat. Med.
  doi: 10.1038/s41591-018-0023-9
  contributor:
    fullname: S Mainardi
– volume: 43
  start-page: 123
  year: 2005
  ident: 2149_CR22
  publication-title: Folia Neuropathol.
  contributor:
    fullname: W Biernat
– volume: 7
  year: 2009
  ident: 2149_CR24
  publication-title: Cell Commun. Signal.
  doi: 10.1186/1478-811X-7-22
  contributor:
    fullname: FU Wöhrle
– volume: 19
  start-page: 533
  year: 2020
  ident: 2149_CR115
  publication-title: Nat. Rev. Drug Discov.
  doi: 10.1038/s41573-020-0068-6
  contributor:
    fullname: AR Moore
– ident: 2149_CR124
  doi: 10.1158/0008-5472.CAN-18-2372
– volume: 10
  start-page: 1073
  year: 2018
  ident: 2149_CR112
  publication-title: Biophys. Rev.
  doi: 10.1007/s12551-018-0434-3
  contributor:
    fullname: Y Liang
– volume: 20
  start-page: 7109
  year: 2000
  ident: 2149_CR32
  publication-title: Mol. Cell. Biol.
  doi: 10.1128/MCB.20.19.7109-7120.2000
  contributor:
    fullname: H Gu
– volume: 6
  start-page: 33091
  year: 2015
  ident: 2149_CR97
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.5173
  contributor:
    fullname: S Kaduwal
– volume: 68
  start-page: 132
  year: 2008
  ident: 2149_CR93
  publication-title: Cancer Res
  doi: 10.1158/0008-5472.CAN-07-1998
  contributor:
    fullname: R Jagadeeswaran
– volume: 18
  start-page: 285
  year: 2017
  ident: 2149_CR12
  publication-title: Nat. Rev. Mol. Cell Biol.
  doi: 10.1038/nrm.2017.7
  contributor:
    fullname: SF Banani
– volume: 22
  start-page: 3035
  year: 2002
  ident: 2149_CR96
  publication-title: Mol. Cell. Biol.
  doi: 10.1128/MCB.22.9.3035-3045.2002
  contributor:
    fullname: A Nguyen
– volume: 13
  start-page: 341
  year: 2004
  ident: 2149_CR35
  publication-title: Mol. Cell
  doi: 10.1016/S1097-2765(04)00050-4
  contributor:
    fullname: SQ Zhang
– volume: 575
  start-page: 299
  year: 2019
  ident: 2149_CR118
  publication-title: Nature
  doi: 10.1038/s41586-019-1730-1
  contributor:
    fullname: N Vasan
– volume: 19
  start-page: 626
  year: 2013
  ident: 2149_CR126
  publication-title: Nat. Med.
  doi: 10.1038/nm.3165
  contributor:
    fullname: KL Jameson
– volume: 2001
  start-page: pe40
  year: 2001
  ident: 2149_CR26
  publication-title: Sci. Signal.
  doi: 10.1126/stke.2001.110.pe40
  contributor:
    fullname: A Sanjay
– ident: 2149_CR68
  doi: 10.1126/scisignal.aav0917
– volume: 33
  start-page: 129
  year: 2014
  ident: 2149_CR84
  publication-title: EMBO J.
  doi: 10.1002/embj.201385946
  contributor:
    fullname: I Bañón-Rodríguez
– volume: 32
  start-page: 107909
  year: 2020
  ident: 2149_CR106
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2020.107909
  contributor:
    fullname: W Yan
– volume: 190
  start-page: 841
  year: 2012
  ident: 2149_CR122
  publication-title: Genetics
  doi: 10.1534/genetics.111.136911
  contributor:
    fullname: G Prelich
– volume: 276
  start-page: 1817
  year: 2009
  ident: 2149_CR11
  publication-title: FEBS J.
  doi: 10.1111/j.1742-4658.2009.06928.x
  contributor:
    fullname: J Omerovic
– volume: 6
  year: 2016
  ident: 2149_CR10
  publication-title: Sci. Rep.
  doi: 10.1038/srep24165
  contributor:
    fullname: O Blaževitš
– volume: 104
  start-page: 19837
  year: 2007
  ident: 2149_CR73
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.0704514104
  contributor:
    fullname: H Vaidyanathan
– volume: 78
  start-page: 4839
  year: 2018
  ident: 2149_CR64
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-17-3629
  contributor:
    fullname: PD Stevens
– volume: 282
  start-page: 32
  year: 2015
  ident: 2149_CR52
  publication-title: FEBS J.
  doi: 10.1111/febs.13113
  contributor:
    fullname: S An
– volume: 16
  start-page: 433
  year: 2009
  ident: 2149_CR63
  publication-title: Dev. Cell
  doi: 10.1016/j.devcel.2009.01.009
  contributor:
    fullname: MC Wilkes
– volume: 96
  start-page: 13259
  year: 1999
  ident: 2149_CR91
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.96.23.13259
  contributor:
    fullname: M Therrien
– volume: 21
  start-page: 499
  year: 2017
  ident: 2149_CR129
  publication-title: Expert Opin. Ther. Targets
  doi: 10.1080/14728222.2017.1311325
  contributor:
    fullname: BK Neilsen
– ident: 2149_CR134
  doi: 10.12688/f1000research.11774.1
– volume: 41
  start-page: 1022
  year: 2009
  ident: 2149_CR108
  publication-title: Nat. Genet.
  doi: 10.1038/ng.425
  contributor:
    fullname: V Cordeddu
– volume: 127
  start-page: 1803
  year: 2016
  ident: 2149_CR100
  publication-title: Blood
  doi: 10.1182/blood-2015-06-653006
  contributor:
    fullname: S Gu
– ident: 2149_CR109
  doi: 10.1093/hmg/ddz108
– volume: 286
  start-page: 309
  year: 1999
  ident: 2149_CR25
  publication-title: Science
  doi: 10.1126/science.286.5438.309
  contributor:
    fullname: CAP Joazeiro
– volume: 22
  start-page: 661
  year: 2012
  ident: 2149_CR18
  publication-title: Cell Res.
  doi: 10.1038/cr.2011.161
  contributor:
    fullname: T Jin
– volume: 25
  start-page: 6056
  year: 2006
  ident: 2149_CR94
  publication-title: Oncogene
  doi: 10.1038/sj.onc.1209635
  contributor:
    fullname: T Yoshida
– volume: 278
  start-page: 14087
  year: 2003
  ident: 2149_CR78
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.C200606200
  contributor:
    fullname: D Kovalenko
– ident: 2149_CR113
  doi: 10.3390/jpm10020020
– volume: 9
  start-page: 304
  year: 2019
  ident: 2149_CR133
  publication-title: Acta Pharm. Sin. B
  doi: 10.1016/j.apsb.2018.08.009
  contributor:
    fullname: M Zhao
– volume: 382
  start-page: 424
  year: 2009
  ident: 2149_CR39
  publication-title: Biochem. Biophys. Res. Commun.
  doi: 10.1016/j.bbrc.2009.03.040
  contributor:
    fullname: PY Chen
– ident: 2149_CR42
  doi: 10.1101/cshperspect.a031500
– volume: 36
  start-page: 2612
  year: 2016
  ident: 2149_CR47
  publication-title: Mol. Cell. Biol.
  doi: 10.1128/MCB.00191-16
  contributor:
    fullname: E Siljamäki
– volume: 286
  start-page: 15010
  year: 2011
  ident: 2149_CR83
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M111.227694
  contributor:
    fullname: DE McNulty
– volume: 15
  start-page: 593
  year: 1995
  ident: 2149_CR23
  publication-title: Mol. Cell. Biol.
  doi: 10.1128/MCB.15.2.593
  contributor:
    fullname: KS Ravichandran
– volume: 113
  start-page: 7497
  year: 2016
  ident: 2149_CR46
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1607298113
  contributor:
    fullname: T Dunzendorfer-Matt
– volume: 26
  start-page: 3113
  year: 2007
  ident: 2149_CR1
  publication-title: Oncogene
  doi: 10.1038/sj.onc.1210394
  contributor:
    fullname: MM McKay
– volume: 89
  start-page: 693
  year: 1997
  ident: 2149_CR33
  publication-title: Cell
  doi: 10.1016/S0092-8674(00)80252-4
  contributor:
    fullname: H Kouhara
– ident: 2149_CR117
– volume: 275
  start-page: 18225
  year: 2000
  ident: 2149_CR21
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M001862200
  contributor:
    fullname: JIS MacDonald
– volume: 18
  start-page: 3966
  year: 1998
  ident: 2149_CR36
  publication-title: Mol. Cell. Biol.
  doi: 10.1128/MCB.18.7.3966
  contributor:
    fullname: YR Hadari
– volume: 54
  start-page: 550
  year: 2017
  ident: 2149_CR110
  publication-title: J. Med. Genet.
  doi: 10.1136/jmedgenet-2016-104432
  contributor:
    fullname: S Guey
– volume: 284
  start-page: 28410
  year: 2009
  ident: 2149_CR55
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M109.001537
  contributor:
    fullname: KL Inder
– volume: 26
  start-page: 3279
  year: 2007
  ident: 2149_CR5
  publication-title: Oncogene
  doi: 10.1038/sj.onc.1210421
  contributor:
    fullname: AS Dhillon
– volume: 58
  start-page: 509
  year: 2015
  ident: 2149_CR38
  publication-title: Eur. J. Med. Genet.
  doi: 10.1016/j.ejmg.2015.08.005
  contributor:
    fullname: M Tajan
– volume: 352
  start-page: 595
  year: 2016
  ident: 2149_CR13
  publication-title: Science
  doi: 10.1126/science.aad9964
  contributor:
    fullname: X Su
– volume: 583
  start-page: 1817
  year: 2009
  ident: 2149_CR95
  publication-title: FEBS Lett.
  doi: 10.1016/j.febslet.2009.05.007
  contributor:
    fullname: CD White
– ident: 2149_CR7
– volume: 9
  start-page: 905
  year: 2007
  ident: 2149_CR15
  publication-title: Nat. Cell Biol.
  doi: 10.1038/ncb1615
  contributor:
    fullname: T Tian
– volume: 53
  start-page: 130
  year: 2018
  ident: 2149_CR3
  publication-title: Crit. Rev. Biochem. Mol. Biol.
  doi: 10.1080/10409238.2018.1431605
  contributor:
    fullname: S Nakhaei-Rad
– volume: 170
  start-page: 17
  year: 2017
  ident: 2149_CR43
  publication-title: Cell
  doi: 10.1016/j.cell.2017.06.009
  contributor:
    fullname: DK Simanshu
– volume: 2
  start-page: 232
  year: 2011
  ident: 2149_CR65
  publication-title: Genes Cancer
  doi: 10.1177/1947601911407323
  contributor:
    fullname: D Matallanas
– volume: 38
  start-page: 6370
  year: 2019
  ident: 2149_CR48
  publication-title: Oncogene
  doi: 10.1038/s41388-019-0883-6
  contributor:
    fullname: Y Cui
– volume: 6
  start-page: 827
  year: 2005
  ident: 2149_CR72
  publication-title: Nat. Rev. Mol. Cell Biol.
  doi: 10.1038/nrm1743
  contributor:
    fullname: W Kolch
– volume: 292
  start-page: 17845
  year: 2017
  ident: 2149_CR17
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M117.802793
  contributor:
    fullname: YH Lin
– ident: 2149_CR59
  doi: 10.1111/febs.15450
– volume: 16
  start-page: 427
  year: 2015
  ident: 2149_CR85
  publication-title: EMBO Rep.
  doi: 10.15252/embr.201439834
  contributor:
    fullname: AC Hedman
– volume: 20
  start-page: 453
  year: 2008
  ident: 2149_CR37
  publication-title: Cell. Signal.
  doi: 10.1016/j.cellsig.2007.10.002
  contributor:
    fullname: M Dance
– volume: 351
  start-page: 289
  year: 2000
  ident: 2149_CR71
  publication-title: Biochem. J.
  doi: 10.1042/bj3510289
  contributor:
    fullname: W Kolch
– ident: 2149_CR99
  doi: 10.1038/s41467-019-10367-x
– volume: 71
  start-page: 391
  year: 2002
  ident: 2149_CR41
  publication-title: Prog. Nucleic Acid Res. Mol. Biol.
  doi: 10.1016/S0079-6603(02)71047-7
  contributor:
    fullname: LA Quilliam
– volume: 1214
  start-page: 99
  year: 2010
  ident: 2149_CR4
  publication-title: Ann. N. Y. Acad. Sci.
  doi: 10.1111/j.1749-6632.2010.05790.x
  contributor:
    fullname: M Tartaglia
– volume: 101
  start-page: 6981
  year: 2004
  ident: 2149_CR86
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.0305894101
  contributor:
    fullname: T Vomastek
– volume: 31
  start-page: 1243
  year: 2007
  ident: 2149_CR125
  publication-title: Int. J. Oncol.
  contributor:
    fullname: AM Tari
– volume: 177
  start-page: 691
  year: 2018
  ident: 2149_CR111
  publication-title: Am. J. Med. Genet. Part B Neuropsychiatr. Genet.
  doi: 10.1002/ajmg.b.32648
  contributor:
    fullname: S Kazeminasab
– volume: 27
  start-page: 542
  year: 2019
  ident: 2149_CR61
  publication-title: Mol. Ther.
  doi: 10.1016/j.ymthe.2019.01.016
  contributor:
    fullname: Z Zheng
– volume: 289
  start-page: 6839
  year: 2014
  ident: 2149_CR51
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M113.527655
  contributor:
    fullname: M Jaiswal
SSID ssj0001999634
Score 2.3776624
SecondaryResourceType review_article
Snippet Health and disease are directly related to the RTK-RAS-MAPK signalling cascade. After more than three decades of intensive research, understanding its...
Abstract Health and disease are directly related to the RTK-RAS-MAPK signalling cascade. After more than three decades of intensive research, understanding its...
Pudewell et al. discuss and advance our understanding of accessory proteins, which are crucial for the RTK-RAS-MAPK signalling cascade. They consider the...
SourceID doaj
pubmedcentral
proquest
crossref
pubmed
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
StartPage 696
SubjectTerms Animals
Biology
Humans
MAP kinase
MAP Kinase Signaling System
Mitogen-Activated Protein Kinases - metabolism
Neoplasms - metabolism
Proteins
ras Proteins - metabolism
Signal Transduction
SummonAdditionalLinks – databaseName: Directory of Open Access Journals
  dbid: DOA
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1La9wwEBYhUOil9JXWeaFCbkXEtt69bUpDaEkIbUNzE9aL5lC7ZDeU_fedkZ1lNwR66VXSQZrReL6xZr4h5KhFpy5tYEpCbCJy5Awi28REE2vlbdY2YTXy-YU6uxKfr-X1WqsvzAkb6YFHwR37OjZtaLxsYxY-xU7llJrgs1VgH34s823kWjBV_q4gjudiqpKpuTmei5KGhRkJSBNmGd_wRIWw_zGU-TBZcs37nD4nzybYSGfjdl-QrdS_JE_GRpLLV-THrPQ9HG6XtBAv3PRzOmQK4I5-nX1j57PLLxR7D__plh_or_ITgWJhSVmBDTspok26GMpARlKDMvKaXJ1--v7xjE0tE1gQVi2YQQAiugAhcgR7ynVKpo5SdlZ3yL0XGx4AEMgmx6yCtkGARIMIIGSdTIp8h2z3Q5_eEiqTCcqaYIVuhQoCIsHWd0F78HoQo4SKvL8Xn_s9MmO48qLNjRuF7UDQrgjb8YqcoIRXK5HVugyArt2ka_cvXVdk_14_bjK1uWvhk200viZX5N1qGowEXz66Pg13ZY2VLZyjqcibUZ2rnYAbL2-xFdEbit7Y6uZMf_OzEHED2NFc8d3_cbY98rQtl1Ox2uyT7cXtXToAvLPwh-Vq_wUJ9_4W
  priority: 102
  providerName: Directory of Open Access Journals
– databaseName: AUTh Library subscriptions: ProQuest Central
  dbid: BENPR
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9QwEB6VVkhcUHmHFmQkbsjaJHYcu5dqi1qtQK2qQkVvVvwqPZCU3VRo_z0eJ7tlEeLq-DCZ8Xi-eXgG4H2JRr1Slooq-iY8OEajZ-spL1wujAq18vga-fRMzC75p6vqagtmq7cwWFa5uhPTRe06izHySRk1U9aYNJw0BqMAtp8c3v6kOD8K86zjMI0HsFMWHBO2O0fHZ-cX9_EWRPaMj-9mciYnC54Ks7BGARuHKco2bFNq4f8v3Pl3-eQf9uhkFx6PQJJMB8k_gS3fPoWHw2jJ5TP4Nk2TELv5kqRWDDftgnSBRLhHLqZf6On0_DPBacS_muUB-ZHCCgSfmqQdOMKTIP4kfZcWArY5SCvP4fLk-OvHGR2HKFDLleipREjCGxudZhc1LOTey9xVVaPqBrvxuYLZCBGqIrggbK0s966x3OauqL30jr2A7bZr_SsglZdWKGkVr0suLI--YWkaW5toB6PXYjP4sGKfvh16ZeiU42ZSD8zWkdE6MVuzDI6Qw-ud2Oc6LXTzaz2qjTaRjNIWpipd4CZSJoL3hTVBiXgajMxgfyUfPSrfQt8flQzerT9HtcFcSNP67i7tUVUZ_6PI4OUgzjUl0bCn7GwG9YagN0jd_NLefE-tuSP8qZlgr_9P1h48KtOxEzSX-7Ddz-_8m4htevN2PLa_AfCT-MI
  priority: 102
  providerName: ProQuest
Title Accessory proteins of the RAS-MAPK pathway: moving from the side line to the front line
URI https://www.ncbi.nlm.nih.gov/pubmed/34103645
https://www.proquest.com/docview/2538877203/abstract/
https://search.proquest.com/docview/2539527241
https://pubmed.ncbi.nlm.nih.gov/PMC8187363
https://doaj.org/article/b0d12c1b52df4beda6fee1cbf96887b8
Volume 4
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3da9swEBdtx2AvY9_z1gUN9jbc2Nb33tzSUjJSQruyvhnrawssdklSSv77nmQ7NGNPezLIMpzvTro73el3CH0pglFnyqScQWxCvSUpRLYupbnNuFZeKBduI08v-Pk1ndywmz3EhrswsWjf6PlR82dx1Mx_x9rK24UZD3Vi49n0BIyMIJyM99G-IORRiB4PVoILT2h_QSYjcryisQIrFCMEhDCVhuY5sHvHFNyOPYqw_f_yNf8umXxkg85eoOe984jLjsiXaM81r9DTrp3k5jX6Wcbuh-1ygyP8wrxZ4dZjcPHwZXmVTsvZdxw6EN_Xm294EY8ScLheEmeEtp04-Jx43cYBH6AN4sgbdH12-uPkPO0bJ6SGKr5OZXBDaG0gULawqnzmnMwsY7USdUDgszkx4Baw3FvPjVCGOlsbajKbCyedJW_RQdM27j3CzEnDlTSKioJyQyEeLHRthAbbB5GKSdDXgX3VbYePUcW8NpFVx_cKeF5FvlckQceBw9uZAds6DrTLX1Uv4UoDGYXJNSuspxoo49653GivOOyIWibocJBP1S-4VVXAxi1FyCkn6PP2NSyVkP-oG9fexTmKFfAfeYLedeLcUjKoQ4LEjqB3SN19A9oZ4bh7bfzw319-RM-KqJw8zeQhOlgv79wncHXWeoSelOXkagLP49OL2eUoHhmMosI_ACmjAME
link.rule.ids 230,315,733,786,790,870,891,2115,21416,27957,27958,33779,33780,43840,53827,53829
linkProvider National Library of Medicine
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9QwEB7BVgguqLxKoAUjcUNWk9hxbC7Vtmq10O6qKq3ozUr8gB6atLtbof33jJ3slkWIq-PDZDzj-ebhGYCPeTDqhTJUFOibcG8ZRc_WUZ7ZVNTKl8qF18jjiRhd8K-XxWUfcJv1ZZXLOzFe1LY1IUa-m6NmyjIkDfdubmmYGhWyq_0IjYewwRm6KgPY2D-cnJ7dR1kCnme8fy2TMrk747EcK1QmhHZhirI1ixQb9_8Lbf5dNPmHFTrahKc9fCTD7ryfwQPXPIdH3UDJxQv4PozzD9vpgsQGDFfNjLSeIMgjZ8NvdDw8PSZhBvGvavGZXMdgAgkPTOKOMLiTBNRJ5m1c8KG5QVx5CRdHh-cHI9qPTqCGKzGnMgARXhl0lS3qlU-dk6ktikqVVejBZzNmEBgUmbdemFIZ7mxluEltVjrpLHsFg6Zt3GsghZNGKGkUL3MuDEc253VlyhqtH_oqJoFPS_bpm65Dho6ZbSZ1x2yNjNaR2ZolsB84vNoZulvHhXb6Q_fKomskIzdZXeTW8xopE965zNReCZSBWiawvTwf3avcTN8LSAIfVp9RWUIGpGpcexf3qCLH_8gS2OqOc0UJmvOYk02gXDvoNVLXvzRXP2NDbgQ9JRPszf_Jeg-PR-fjE33yZXL8Fp7kUQQFTeU2DObTO7eD6GZev-tF-DfQ-Pf1
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lj9MwEB7BIhAX3o_AAkbihtK8HCfmVhaqhaWrClix4mLFL6igSdWmQuXXM3bSql1x2qvtSOPMjGfGM_4G4FXqjHrOVchyjE2o1VmIka0JaaJjJrktuHGvkcen7PiMfjzPz3daffmifSWng_r3bFBPf_rayvlMRZs6sWgyPkIjU2Qsi-baRlfhGupsyncCdX-94hz5jPbPZOKsjJbU12G5kgSHE8ZD10IHz3CfiNuzSh68_38e58XCyR1LNLoN3zd76ApQfg1WrRyovxfgHS-1yTtwq_dPybBbcheumPoeXO86Vq7vw7ehb7DYLNbEIzxM6yVpLEEvknwefgnHw8kJcU2O_1TrN2TmbyuIe8HiV7jOoMS5taRt_IB16Al-5AGcjd5_PToO-94MoaKctWHpPB1aKYzFNSqujY0pY53nFS8qB_Knk0yh55EnVlumCq6o0ZWiKtZJYUqjs4dwUDe1eQwkN6VivFScFillimLImcpKFRLNKwZDKoDXG96IeQfBIXzqPCtFx1SBDBWeqSIL4K1j33alg8_2A83ih-j_r5BIRqoSmafaUomUMWtMoqTlDA9dWQZwuGG-6HV6KVKUs7JwaesAXm6nURtdiqWqTbPya3ie4j6SAB51srKlZCNrARR7UrRH6v4MyoZH_O5l4cmlv3wBNybvRuLTh9OTp3Az9UrAwrg8hIN2sTLP0LFq5XOvQv8AkcAhIg
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Accessory+proteins+of+the+RAS-MAPK+pathway%3A+moving+from+the+side+line+to+the+front+line&rft.jtitle=Communications+biology&rft.au=Pudewell%2C+Silke&rft.au=Wittich%2C+Christoph&rft.au=Kazemein+Jasemi%2C+Neda+S.&rft.au=Bazgir%2C+Farhad&rft.date=2021-06-08&rft.issn=2399-3642&rft.eissn=2399-3642&rft.volume=4&rft.issue=1&rft_id=info:doi/10.1038%2Fs42003-021-02149-3&rft.externalDBID=n%2Fa&rft.externalDocID=10_1038_s42003_021_02149_3
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2399-3642&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2399-3642&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2399-3642&client=summon