Accessory proteins of the RAS-MAPK pathway: moving from the side line to the front line

Health and disease are directly related to the RTK-RAS-MAPK signalling cascade. After more than three decades of intensive research, understanding its spatiotemporal features is afflicted with major conceptual shortcomings. Here we consider how the compilation of a vast array of accessory proteins m...

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Bibliographic Details
Published inCommunications biology Vol. 4; no. 1; p. 696
Main Authors Pudewell, Silke, Wittich, Christoph, Kazemein Jasemi, Neda S, Bazgir, Farhad, Ahmadian, Mohammad R
Format Journal Article
LanguageEnglish
Published England Nature Publishing Group 08.06.2021
Nature Publishing Group UK
Nature Portfolio
Subjects
Animals
Biology
Humans
MAP kinase
MAP Kinase Signaling System
Mitogen-Activated Protein Kinases - metabolism
Neoplasms - metabolism
Proteins
ras Proteins - metabolism
Signal Transduction
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Summary:Health and disease are directly related to the RTK-RAS-MAPK signalling cascade. After more than three decades of intensive research, understanding its spatiotemporal features is afflicted with major conceptual shortcomings. Here we consider how the compilation of a vast array of accessory proteins may resolve some parts of the puzzles in this field, as they safeguard the strength, efficiency and specificity of signal transduction. Targeting such modulators, rather than the constituent components of the RTK-RAS-MAPK signalling cascade may attenuate rather than inhibit disease-relevant signalling pathways.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:2399-3642
2399-3642
DOI:10.1038/s42003-021-02149-3