Non-redundant functions of EMT transcription factors

Epithelial-mesenchymal transition (EMT) is a crucial embryonic programme that is executed by various EMT transcription factors (EMT-TFs) and is aberrantly activated in cancer and other diseases. However, the causal role of EMT and EMT-TFs in different disease processes, especially cancer and metasta...

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Published inNature cell biology Vol. 21; no. 1; pp. 102 - 112
Main Authors Stemmler, Marc P, Eccles, Rebecca L, Brabletz, Simone, Brabletz, Thomas
Format Journal Article
LanguageEnglish
Published England Nature Publishing Group 01.01.2019
Subjects
Animals
Cancer
Cancer metastasis
DNA binding proteins
Embryonic development
Embryonic Development - genetics
Embryos
Epithelial-Mesenchymal Transition - genetics
Gene expression
Gene Expression Profiling
Gene Expression Regulation, Neoplastic
Genetic aspects
Homeostasis
Humans
Mesenchyme
Metastases
Models, Genetic
Neoplasms - genetics
Neoplasms - pathology
Stem cells
Transcription factors
Transcription Factors - genetics
Universities and colleges
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Summary:Epithelial-mesenchymal transition (EMT) is a crucial embryonic programme that is executed by various EMT transcription factors (EMT-TFs) and is aberrantly activated in cancer and other diseases. However, the causal role of EMT and EMT-TFs in different disease processes, especially cancer and metastasis, continues to be debated. In this Review, we identify and describe specific, non-redundant functions of the different EMT-TFs and discuss the reasons that may underlie disputes about EMT in cancer.
Bibliography:ObjectType-Article-2
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ObjectType-Review-1
ISSN:1465-7392
1476-4679
DOI:10.1038/s41556-018-0196-y