Carbohydrate Sensing Through the Transcription Factor ChREBP
Carbohydrate response element binding protein (ChREBP) is a carbohydrate-signaling transcription factor that in the past years has emerged as a central metabolic regulator. ChREBP expression is mostly abundant in active sites of lipogenesis including liver and white and brown adipose tissues. ChREBP...
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Published in | Frontiers in genetics Vol. 10; p. 472 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
Switzerland
Frontiers Media
04.06.2019
Frontiers Media S.A |
Subjects | |
Online Access | Get full text |
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Summary: | Carbohydrate response element binding protein (ChREBP) is a carbohydrate-signaling transcription factor that in the past years has emerged as a central metabolic regulator. ChREBP expression is mostly abundant in active sites of
lipogenesis including liver and white and brown adipose tissues. ChREBP is also expressed in pancreatic islets, small intestine and to a lesser extent in the kidney and the brain. In response to glucose, ChREBP undergoes several post-translational modifications (PTMs) (phosphorylation, acetylation and/or
-GlcNAcylation) that will either modulate its cellular location, stability and/or its transcriptional activity. ChREBPβ is a shorter isoform of ChREBP that was first described in adipose tissue and later found to be expressed in other sites including liver and pancreatic β cells. ChREBPβ lacks an important regulatory inhibitory domain, known as LID (low glucose inhibitory domain), in its N-terminal domain and is therefore reported as a highly active isoform. In this review, we recapitulate a recent progress concerning the mechanisms governing the activity of the ChREBP isoforms, including PTMs, partners/cofactors as well as novel metabolic pathways regulated by ChREBP in key metabolic tissues, by discussing phenotypes associated with tissue-specific deletion of ChREBP in knockout mice. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 PMCID: PMC6593282 Edited by: Jane Mellor, University of Oxford, United Kingdom This article was submitted to Epigenomics and Epigenetics, a section of the journal Frontiers in Genetics Reviewed by: Essi M. Havula, The University of Sydney, Australia; Maurizio D’Esposito, Italian National Research Council (CNR), Italy |
ISSN: | 1664-8021 1664-8021 |
DOI: | 10.3389/fgene.2019.00472 |