Cytokine upsurge among drug-resistant tuberculosis endorse the signatures of hyper inflammation and disease severity

• Published in: Scientific reports Vol. 13; no. 1; p. 785
• Main Authors: Sampath, Pavithra, Rajamanickam, Anuradha, Thiruvengadam, Kannan, Natarajan, Alangudi Palaniappan, Hissar, Syed, Dhanapal, Madhavan, Thangavelu, Bharathiraja, Jayabal, Lavanya, Ramesh, Paranchi Murugesan, Ranganathan, Uma Devi, Babu, Subash, Bethunaickan, Ramalingam
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 16.01.2023; Nature Publishing Group UK; Nature Portfolio
• Subjects: Antigens, Bacterial; Biomarkers; Cytokines; Demographics; Drug resistance; Humans; Immune response; Infections; Inflammation; Interleukin 10; Interleukin 17; Interleukin 2; Interleukin 5; Interleukin 6; Latent infection; Latent Tuberculosis; Mycobacterium tuberculosis; Pathology; Patient Acuity; Plasma; Principal components analysis; Software; Tuberculosis; Tuberculosis, Multidrug-Resistant - drug therapy; Tumor necrosis factor-α; γ-Interferon
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-023-27895-8

Tuberculosis (TB) elimination is possible with the discovery of accurate biomarkers that define the stages of infection. Drug-resistant TB impair the current treatment strategies and worsen the unfavourable outcomes. The knowledge on host immune responses between drug-sensitive and drug-resistant infection is inadequate to understand the pathophysiological differences and disease severity. The secreted proteins, cytokines display versatile behaviour upon infection with Mycobacterium tuberculosis (MTB) and their imbalances often tend to assist disease pathology than protection. Therefore, studying these soluble proteins across TB infection spectrum (drug-resistant TB, drug-sensitive TB, and latent TB) may unveil the disease mediated responses and unique stage specific cytokine signatures. Thus, we sought to determine the plasma cytokine levels from healthy, latently infected, drug-sensitive, and drug-resistant TB individuals. Our study revealed top 8 cytokines (IL-17, IL-1α, IL-2, IL-10, IL-5, IFN-γ, TNF-α and IL-6) and their biomarker abilities to discriminate different stages of infection.