The role of extracellular vesicles when innate meets adaptive

• Published in: Seminars in immunopathology Vol. 40; no. 5; pp. 439 - 452
• Main Authors: Groot Kormelink, Tom, Mol, Sanne, de Jong, Esther C., Wauben, Marca H. M.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.09.2018; Springer Nature B.V
• Subjects: Adaptive immunity; Adaptive Immunity - physiology; Animals; Biomedical and Life Sciences; Biomedicine; Cell Communication - immunology; Cell interactions; Cell signaling; Dendritic cells; Extracellular vesicles; Extracellular Vesicles - immunology; Humans; Immune response; Immune system; Immunity, Innate - physiology; Immunology; Internal Medicine; Leukocytes (basophilic); Leukocytes (eosinophilic); Leukocytes (neutrophilic); Lymphocyte receptors; Lymphocytes B; Macrophages; Mast cells; Review; T cell receptors; Microparticle; Innate immune cells; Adaptive immunity; Extracellular vesicle; Exosome; Microvesicle
• ISSN: 1863-2297; 1863-2300
• DOI: 10.1007/s00281-018-0681-1

Innate immune cells are recognized for their rapid and critical contribution to the body’s first line of defense against invading pathogens and harmful agents. These actions can be further amplified by specific adaptive immune responses adapted to the activating stimulus. Recently, the awareness has grown that virtually all innate immune cells, i.e., mast cells, neutrophils, macrophages, eosinophils, basophils, and NK cells, are able to communicate with dendritic cells (DCs) and/or T and B cells, and thereby significantly contribute to the orchestration of adaptive immune responses. The means of communication that are thus far primarily associated with this function are cell-cell contacts and the release of a broad range of soluble mediators. Moreover, the possible contribution of innate immune cell-derived extracellular vesicles (EVs) to the modulation of adaptive immunity will be outlined in this review. EVs are submicron particles composed of a lipid bilayer, proteins, and nucleic acids released by cells in a regulated fashion. EVs are involved in intercellular communication between multiple cell types, including those of the immune system. A good understanding of the mechanisms by which innate immune cell-derived EVs influence adaptive immune responses, or vice versa, may reveal novel insights in the regulation of the immune system and can open up new possibilities for EVs (or their components) in controlling immune responses, either as a therapy, target, or as an adjuvant in future immune modulating treatments.