Cardiovascular and Sympathetic Nervous Response to Dynamic Exercise in Patients with Essential Hypertension

• Published in: Internal Medicine Vol. 31; no. 5; pp. 606 - 610
• Main Authors: SAITOH, Makoto, MIYAKODA, Hiroyuki, KITAMURA, Hideyuki, KINUGAWA, Toru, HISATOME, Ichiro, KOTAKE, Hiroshi, MASHIBA, Hiroto
• Format: Journal Article
• Language: English
• Published: Japan The Japanese Society of Internal Medicine 1992
• Subjects: Adult; Blood Pressure - physiology; Cardiomegaly - etiology; Cardiomegaly - physiopathology; Cardiovascular System - physiopathology; Exercise - physiology; Exercise Test; Female; Humans; Hypertension - blood; Hypertension - complications; Hypertension - physiopathology; left ventricular hypertrophy; Male; Middle Aged; Norepinephrine - blood; plasma norepinephrine; Sympathetic Nervous System - physiopathology; systolic blood pressure
• ISSN: 0918-2918; 1349-7235
• DOI: 10.2169/internalmedicine.31.606

To investigate the relationship among systolic blood pressure (SBP) during exercise (EX), left ventricular hypertrophy (LVH) and plasma norepinephrine concentration (NE) in patients with essential hypertension (HT), 20 patients with HT and 20 age- and sex-matched normal subjects were studied using treadmill testing. According to the change in SBP from rest to EX (ΔSBP), patients with HT were classified into two groups (group I, n=12, ΔSBP < 72mmHg : group II, n=8, ΔSBP ?? 72mmHg).There were no significant differences between the two groups with regard to SBP at rest, NE at rest and NE on EX. However, SBP at peak EX, ΔSBP and the incidence of LVH were greater in group II than in group I. We conclude that exaggerated SBP response to EX in patients with HT is related to LVH. (Internal Medicine 31 : 606-610, 1992)