ENANTIOSELECTIVE SYNTHESIS OF (-)-PHYSOSTIGMINE

The first enantioselective synthesis of (-)-physostigmine (1), a potent cholinesterase-inhibiting alkaloid from Physostigma venenosum Balf., has been accomplished using (S)-(-)-benzyl 2, 3-epoxypropyl ether (5) as a chiral synthon.

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Bibliographic Details
Published inChemical & pharmaceutical bulletin Vol. 30; no. 7; pp. 2641 - 2643
Main Authors Takano, Seiichi, Ogasawara, Kunio, Goto, Emiko, Hirama, Michiyasu
Format Journal Article
LanguageEnglish
Published The Pharmaceutical Society of Japan 01.01.1982
Subjects
cholinesterase inhibitor
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ISSN0009-2363
1347-5223
DOI10.1248/cpb.30.2641

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Summary:The first enantioselective synthesis of (-)-physostigmine (1), a potent cholinesterase-inhibiting alkaloid from Physostigma venenosum Balf., has been accomplished using (S)-(-)-benzyl 2, 3-epoxypropyl ether (5) as a chiral synthon.
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.30.2641