Effect of experimental diabetes on craniofacial growth in rats

• Published in: Archives of oral biology Vol. 53; no. 9; pp. 819 - 825
• Main Authors: Abbassy, Mona Aly, Watari, Ippei, Soma, Kunimichi
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.09.2008
• Subjects: Advanced Basic Science; Animals; Blood Glucose - metabolism; Body Weight; Cephalometric analysis; Cephalometry; Craniofacial growth; Dentistry; Diabetes Mellitus, Experimental - physiopathology; Diabetes Mellitus, Type 1 - physiopathology; Male; Radiography; Random Allocation; Rats; Rats, Wistar; Skull - diagnostic imaging; Skull - growth & development; Streptozotocin (STZ); Type 1 diabetes mellitus (T1DM); Craniofacial growth; Type 1 diabetes mellitus (T1DM); Cephalometric analysis; Streptozotocin (STZ)
• ISSN: 0003-9969; 1879-1506
• DOI: 10.1016/j.archoralbio.2008.02.008

Abstract Objectives The goal of this study was to assess the effect of type 1 diabetes mellitus (T1DM) on the craniofacial growth and skeletal maturation using the STZ-DM rat model. Design Experimental T1DM was induced in 3-week-old male Wistar rats by a single dose of 60 mg/kg body weight of streptozotocin (STZ). Lateral and dorsoventral X-rays of the head were taken at the age of 7 weeks. The X-rays were scanned, digitised and selected linear distances were measured and analysed statistically. Results In STZ-DM statistical analysis of results revealed a reduction in growth of most of the linear measurements in the neurocranium and mandible by X-ray analysis, and all measurements were significantly lower in viscerocranium. Conclusions Uncontrolled T1DM reduces craniofacial growth, resulting in retardation of skeletal development.