Psychosocial adjustment and quality of life among multiple myeloma patients undergoing evaluation for autologous stem cell transplantation

• Published in: Bone marrow transplantation (Basingstoke) Vol. 33; no. 9; pp. 955 - 962
• Main Authors: SHERMAN, A. C, SIMONTON, S, LATIF, U, SPOHN, R, TRICOT, G
• Format: Journal Article
• Language: English
• Published: Basingstoke Nature Publishing Group 01.05.2004
• Subjects: Adaptation, Psychological; Adult; Aged; Aged, 80 and over; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Anxiety; Autografts; Biological and medical sciences; Bone marrow; Bone marrow, stem cells transplantation. Graft versus host reaction; Care and treatment; Depression; Diagnosis; Evaluation; Female; Health aspects; Hematopoietic stem cells; Humans; Immunodeficiencies. Immunoglobulinopathies; Immunoglobulinopathies; Immunopathology; Male; Medical sciences; Mental depression; Middle Aged; Multiple myeloma; Multiple Myeloma - psychology; Multiple Myeloma - therapy; Norms; Pain; Patients; Quality of Life; Stem cell transplantation; Stem Cell Transplantation - methods; Stem Cell Transplantation - psychology; Stem cells; Stress, Psychological; Transfusions. Complications. Transfusion reactions. Cell and gene therapy; Transplantation; Transplantation, Autologous - methods; Transplantation, Autologous - psychology; Treatment Outcome; United States; Human; Immunopathology; multiple myeloma; Hematology; Adjustment; Stem cell; Hematopoietic cell; psychosocial adjustment; Malignant hemopathy; peripheral stem cell transplantation; Myeloma; Quality of life; Autograft; Immunoglobulinopathy; Lymphoproliferative syndrome; Graft; Social aspect
• ISSN: 0268-3369; 1476-5365
• DOI: 10.1038/sj.bmt.1704465

Stem cell transplantation has assumed a prominent place in the treatment of multiple myeloma, but relative to patients with other malignancies there is surprisingly little information about the adjustment difficulties and quality-of-life changes that these patients experience. This study examined psychosocial and functional deficits among myeloma patients assessed at a uniform period during their initial diagnostic evaluation, prior to beginning protocols at a transplant center. Validated self-report measures and clinician rating scales were used to assess 213 patients. Outcomes evaluated included emotional distress (Hospital Anxiety and Depression Scale, Brief Symptom Inventory), depression (Hamilton Depression Rating Scale), physical functioning, pain, and energy (SF-12). A significant proportion of patients experienced compromised psychosocial and physical functioning. Roughly one-third reported clinically elevated levels of distress, anxiety, and depression. In all, 59% scored below age-adjusted norms for daily physical functioning, 58% reported at least moderate levels of pain, and over 80% noted at least moderate fatigue. Clinical and demographic correlates of these outcomes were examined. These findings are among the first to characterize quality-of-life outcomes among myeloma patients in the transplant setting, and indicate that many patients experience considerable supportive care needs even prior to beginning aggressive regimens. Results highlight the importance of early screening.