Targeted Walking in Incomplete Spinal Cord Injury: Role of Corticospinal Control

• Published in: Journal of neurotrauma Vol. 37; no. 21; pp. 2302 - 2314
• Main Authors: Meyer, Christian, Filli, Linard, Stalder, Stephanie A, Awai Easthope, Christopher, Killeen, Tim, von Tscharner, Vinzenz, Curt, Armin, Zörner, Björn, Bolliger, Marc
• Format: Journal Article
• Language: English
• Published: United States Mary Ann Liebert, Inc 01.11.2020
• Subjects: Adaptation; Electromyography; Feet; Fitness equipment; Gait; Kinematics; Locomotion; Medical screening; Muscle function; Neuromuscular system; Pyramidal tracts; Rehabilitation; Spinal cord injuries; Walking; Switzerland; targeted walking; corticospinal control; electromyography; neuromuscular control; corticospinal assessment; locomotion
• ISSN: 0897-7151; 1557-9042
• DOI: 10.1089/neu.2020.7030

Locomotor recovery after incomplete spinal cord injury (iSCI) is influenced by spinal and supraspinal networks. Conventional clinical gait analysis fails to differentiate between these components. There is evidence that corticospinal control is enhanced during targeted walking, where each foot must be continuously placed on visual targets in randomized order. This study investigates the potential of targeted walking in the functional assessment of corticospinal integrity. Twenty-one controls and 16 individuals with chronic iSCI performed normal and targeted walking on a treadmill while electromyograms (EMGs) and kinematics were recorded. Precision (% of accurate foot placements) in targeted walking was significantly lower in individuals with iSCI (82.9 ± 14.7%, controls: 94.9 ± 4.0%). Although the overall kinematic pattern was comparable between walking conditions, controls showed significantly higher semitendinosus (ST) activity before heel-strike during targeted walking. This was accompanied by a shift of relative EMG intensity from 90-120 Hz to lower frequencies of 20-60 Hz, previously associated with corticospinal control of muscle activity. Targeted walking in individuals with iSCI evoked smaller EMG changes, suggesting that the switch to more corticospinal control is impaired. Accordingly, mildly impaired iSCI individuals revealed higher adaptations to the targeted walking task than more-impaired individuals. Recording of EMGs during targeted walking holds potential as a research tool to reveal further insights into the neuromuscular control of locomotion. It also complements findings of pre-clinical studies and is a promising novel surrogate marker of integrity of corticospinal control in individuals with iSCI and other neurological impairments. Future studies should investigate its potential for diagnosis or tracking recovery during rehabilitation.