Insulin in w/o/w multiple emulsions: biological activity after oral administration in normal and diabetic rats

In this work the biological effects of two w/o/w multiple emulsions composed of the soybean oil (EHS) or medium-chain triglycerides (ETCM), containing insulin, were studied. The release mechanism of insulin from multiple emulsions proposed in our previous in-vitro investigations was confirmed by sub...

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Bibliographic Details
Published inJournal of microencapsulation Vol. 14; no. 3; p. 321
Main Authors Cunha, A S, Grossiord, J L, Puisieux, F, Seiller, M
Format Journal Article
LanguageEnglish
Published England 1997
Subjects
Administration, Oral
Animals
Blood Glucose - metabolism
Body Weight - drug effects
Diabetes Mellitus, Experimental - blood
Diabetes Mellitus, Experimental - drug therapy
Emulsions
Glycosuria - drug therapy
Humans
Hypoglycemic Agents - administration & dosage
Hypoglycemic Agents - pharmacology
Injections, Subcutaneous
Insulin - administration & dosage
Insulin - pharmacology
Male
Rats
Rats, Wistar
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Summary:In this work the biological effects of two w/o/w multiple emulsions composed of the soybean oil (EHS) or medium-chain triglycerides (ETCM), containing insulin, were studied. The release mechanism of insulin from multiple emulsions proposed in our previous in-vitro investigations was confirmed by subcutaneous administration. This mechanism is the swelling-breakdown phenomenon which occurs when the emulsions are diluted under hypo-osmotic condition. The biological effect after oral administration, evaluated in two experimental protocols, single administration in normal and diabetic rats and short-term treatment in diabetic rats, shows that in diabetic rats small amounts of biologically active insulin were absorbed from these emulsions. In these experiments no significant difference between EHS and ETCM was found.
ISSN:0265-2048
1464-5246
DOI:10.3109/02652049709051136