An efficient synthesis of enantiopure (R)-heteroarylpyrimidine analogs

An efficient synthesis of enantiopure (R)-heteroarylpyrimidine analogs is described here, which involves introduction of a chiral group, formation and separation of diasteroisomers and final transformation of an amide to an ester. The absolute configuration of the enantiopure HAPs is confirmed by X-...

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Published inMolecules (Basel, Switzerland) Vol. 18; no. 9; pp. 11144 - 11152
Main Authors Yang, Xiu-Yan, Xia, Guang-Qiang, Wang, Xiao-Kui, Zheng, Zhi-Bing, Zhao, Dong-Mei, Zhao, Guo-Ming, Li, Song
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 11.09.2013
MDPI
Subjects
(R)-heteroarylpyrimidines
Acids
anti-HBV
chiral separation
Crystallography, X-Ray
diastereomer
enantiopure
Hepatitis B
Models, Molecular
Molecular Conformation
Pyrimidines - chemical synthesis
Pyrimidines - isolation & purification
Stereoisomerism
Beijing China
China
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Summary:An efficient synthesis of enantiopure (R)-heteroarylpyrimidine analogs is described here, which involves introduction of a chiral group, formation and separation of diasteroisomers and final transformation of an amide to an ester. The absolute configuration of the enantiopure HAPs is confirmed by X-ray analysis of their intermediates.
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SourceType-Scholarly Journals-1
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These authors contributed equally to this work.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules180911144