Quantification of myocardial strain in patients with isolated left ventricular non-compaction and healthy subjects using deformable registration algorithm: comparison with feature tracking

• Published in: BMC cardiovascular disorders Vol. 20; no. 1; pp. 400 - 9
• Main Authors: Liu, Jia, Li, Yumin, Cui, Yue, Cao, Yukun, Yao, Sheng, Zhou, Xiaoyue, Wetzl, Jens, Zeng, Wenjuan, Shi, Heshui
• Format: Journal Article
• Language: English
• Published: England BioMed Central 03.09.2020; BMC
• Subjects: Adult; Agreements; Algorithms; Cardiac function; Cardiac magnetic resonance; Cardiovascular disease; Compaction; Congenital diseases; Correlation analysis; Deformable registration algorithm; Ejection fraction; Feature tracking; Female; Heart; Humans; Image Interpretation, Computer-Assisted; Isolated left ventricular non-compaction; Isolated Noncompaction of the Ventricular Myocardium - diagnostic imaging; Isolated Noncompaction of the Ventricular Myocardium - physiopathology; Magnetic Resonance Imaging, Cine; Male; Middle Aged; Myocardial strain; Normal distribution; Predictive Value of Tests; Reproducibility; Reproducibility of Results; Retrospective Studies; Systole; Ventricle; Ventricular Dysfunction, Left - diagnostic imaging; Ventricular Dysfunction, Left - physiopathology; Ventricular Function, Left; Young Adult; Germany; Deformable registration algorithm; Feature tracking; Myocardial strain; Reproducibility; Cardiac magnetic resonance; Isolated left ventricular non-compaction; Ejection fraction
• ISSN: 1471-2261; 1471-2261
• DOI: 10.1186/s12872-020-01668-x

Systolic dysfunction of the left ventricle is frequently associated with isolated left ventricular non-compaction (iLVNC). Clinically, the ejection fraction (EF) is the primary index of cardiac function. However, changes of EF usually occur later in the disease course. Feature tracking (FT) and deformable registration algorithm (DRA) have become appealing techniques for myocardial strain assessment. Thirty patients with iLVNC (36.7 ± 13.3 years old) and fifty healthy volunteers (42.3 ± 13.6 years old) underwent cardiovascular magnetic resonance (CMR) examination on a 1.5 T MR scanner. Strain values in the radial, circumferential, longitudinal directions were analyzed based on the short-axis and long-axis cine images using FT and DRA methods. The iLVNC patients were further divided based on the ejection fraction, into EF ≥ 50% group (n = 11) and EF < 50% group (n = 19). Receiver-operating-characteristic (ROC) analysis was performed to assess the diagnostic performance of the global strain values. Intraclass correlation coefficient (ICC) analysis was used to evaluate the intra- and inter-observer agreement. Global radial strain (GRS) was statistically lower in EF ≥ 50% group compared with control group [GRS (DRA)/% vs. controls: 34.6 ± 7.0 vs. 37.6 ± 7.2, P < 0.001; GRS (FT)/% vs. controls: 37.4 ± 13.2 vs. 56.9 ± 16.4, P < 0.01]. ROC analysis of global strain values derived from DRA and FT demonstrated high area under curve (range, 0.743-0.854). DRA showed excellent intra- and inter-observer agreement of global strain in both iLVNC patients (ICC: 0.995-0.999) and normal controls (ICC: 0.934-0.996). While for FT analysis, global radial strain of normal controls showed moderate intra-observer (ICC: 0.509) and poor inter-observer agreement (ICC: 0.394). In patients with iLVNC, DRA can be used to quantitatively analyze the strain of left ventricle, with global radial strain being an earlier marker of LV systolic dysfunction. DRA has better reproducibility in evaluating both the global and segmental strain.