Guignardones P-S, New Meroterpenoids from the Endophytic Fungus Guignardia mangiferae A348 Derived from the Medicinal Plant Smilax glabra

• Published in: Molecules (Basel, Switzerland) Vol. 20; no. 12; pp. 22900 - 22907
• Main Authors: Sun, Zhang-Hua, Liang, Fa-Liang, Wu, Wen, Chen, Yu-Chan, Pan, Qing-Ling, Li, Hao-Hua, Ye, Wei, Liu, Hong-Xin, Li, Sai-Ni, Tan, Guo-Hui, Zhang, Wei-Min
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 21.12.2015; MDPI
• Subjects: Ascomycota - chemistry; Cancer; Cell Line, Tumor; Cell proliferation; Cell Proliferation - drug effects; Communication; Crystallography, X-Ray - methods; Diffraction; Endophytes; endophytic fungus; Fungi; Guignardia mangiferae; Humans; Mangifera - chemistry; MCF-7 Cells; meroterpenoids; Plants, Medicinal - chemistry; Plants, Medicinal - microbiology; Single crystals; Smilax - chemistry; Smilax - microbiology; Smilax glabra; structure identification; Terpenes - chemistry; Terpenes - pharmacology; Tumor cell lines; X-ray diffraction; X-Ray Diffraction - methods; endophytic fungus; Smilax glabra; meroterpenoids; Guignardia mangiferae; structure identification
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules201219890

Four new meroterpenoids, guignardones P-S (1-4), and three known analogues (5-7) were isolated from the endophytic fungal strain Guignardia mangiferae A348. Their structures were elucidated on the basis of spectroscopic analysis and single crystal X-ray diffraction. All the isolated compounds were evaluated for their inhibitory effects on SF-268, MCF-7, and NCI-H460 human cancer cell lines. Compounds 2 and 4 exhibited weak inhibitions of cell proliferation against MCF-7 cell line.