New consensus nomenclature for mammalian keratins

Keratins are intermediate filament-forming proteins that provide mechanical support and fulfill a variety of additional functions in epithelial cells. In 1982, a nomenclature was devised to name the keratin proteins that were known at that point. The systematic sequencing of the human genome in rece...

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Published inThe Journal of cell biology Vol. 174; no. 2; pp. 169 - 174
Main Authors Schweizer, Jürgen, Bowden, Paul E, Coulombe, Pierre A, Langbein, Lutz, Lane, E. Birgitte, Magin, Thomas M, Maltais, Lois, Omary, M. Bishr, Parry, David A.D, Rogers, Michael A, Wright, Mathew W
Format Journal Article
LanguageEnglish
Published United States The Rockefeller University Press 17.07.2006
Rockefeller University Press
Subjects
Animals
Chromosomes
Comment
Genes
Hair
Human genome
Human hair
Humans
Keratins
Keratins - chemistry
Keratins - classification
Keratins - genetics
Mammals
Pseudogenes
Pseudogenes - genetics
Reviews
Terminology
Terminology as Topic
Type I keratins
Type II keratins
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Summary:Keratins are intermediate filament-forming proteins that provide mechanical support and fulfill a variety of additional functions in epithelial cells. In 1982, a nomenclature was devised to name the keratin proteins that were known at that point. The systematic sequencing of the human genome in recent years uncovered the existence of several novel keratin genes and their encoded proteins. Their naming could not be adequately handled in the context of the original system. We propose a new consensus nomenclature for keratin genes and proteins that relies upon and extends the 1982 system and adheres to the guidelines issued by the Human and Mouse Genome Nomenclature Committees. This revised nomenclature accommodates functional genes and pseudogenes, and although designed specifically for the full complement of human keratins, it offers the flexibility needed to incorporate additional keratins from other mammalian species.
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Correspondence to Jürgen Schweizer: schweizer@dkfz.de
Abbreviation used in this paper: HGNC, Human Genome Nomenclature Committee.
ISSN:0021-9525
1540-8140
DOI:10.1083/jcb.200603161