Association between ambient particulate matter and semen quality parameters: a systematic review and meta-analysis

• Published in: Middle East Fertility Society Journal Vol. 29; no. 1; pp. 2 - 11
• Main Authors: Bahreiny, Seyed Sobhan, Bastani, Mohammad-Navid, Dabbagh, Mohammad Reza, Ghorbani, Hamid, Aghaei, Mojtaba, Zahedian, Mehdi, Fard, Reza Mohammadpour
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.12.2024; Springer; Springer Nature B.V; SpringerOpen
• Subjects: Air pollution; Ambient air pollution; Analysis; Body mass index; Cross-sectional studies; Embryology; Infectious Diseases; Infertility; Investigations; Longitudinal studies; Medicine; Medicine & Public Health; Meta-analysis; Motility; Observational studies; Outdoor air quality; Particulate matter; Public health; Reproductive health; Reproductive Medicine; Review; rology; Semen quality; Sperm; Stem Cells; Systematic review; Iran; China; United States > US; Semen quality; Particulate matter; Ambient air pollution; Meta-analysis
• ISSN: 1110-5690; 2090-3251
• DOI: 10.1186/s43043-023-00162-6

Background The adverse consequences of ambient particulate matter (PM) on human health have been extensively studied. However, the association between PM2.5 and PM10 μm, two common sizes of particulate matter, and semen quality remains a subject of debate. This systematic review and meta-analysis aim to investigate the relationship between ambient PM2.5 and PM10 μm exposure and semen quality parameters. Main text A systematic literature search was conducted using electronic databases to identify relevant studies investigating the association between (PM2.5 μm and PM10 μm) exposure and semen quality, covering the period from January 2000 to April 2023. Standard mean difference (SMD) was used to calculate pooled effect estimates with 95% confidence intervals (CIs). Furthermore, meta-regression and subgroup analyses provided additional insight into potential factors contributing to heterogeneity. The meta-analysis included a comprehensive review of nine studies with a total of 6264 participants. The findings demonstrated a significant negative correlation between ambient exposure to PM2.5 μm and PM10 μm and various parameters related to semen quality. The analysis revealed that PM2.5 exposure was linked to reduced semen volume (SMD = −0.028; 95% CI −0.055 to −0.01), total sperm count (SMD = −0.027; 95% CI −0.052 to -0.02), sperm motility (SMD = −0.156; 95% CI −0.26 to -0.04), and progressive motility (SMD = −0.194; 95% CI −0.38 to −0.01). Likewise, exposure to PM10 was associated with decreased sperm concentration (SMD = −0.036; 95% CI −0.06 to −0.01) and sperm motility (SMD = −0.93; 95% CI −0.15 to −0.02). Conclusion This systematic review and meta-analysis demonstrate a consistent negative association between ambient PM10 and PM2.5 μm exposure and semen quality parameters. The findings suggest that increased levels of ambient particulate matter may have an adverse influence on sperm count and motility. The results highlight the importance of addressing environmental air pollution as a potential risk factor for male reproductive health.