Maternal antenatal peanut consumption and peanut and rye sensitization in the offspring at adolescence

• Published in: Clinical and experimental allergy Vol. 41; no. 2; pp. 224 - 231
• Main Authors: Kemp, A. S., Ponsonby, A-L, Dwyer, T., Cochrane, J. A., Pezic, A., Jones, G.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.02.2011; Blackwell; Wiley Subscription Services, Inc
• Subjects: Adolescence; Adolescent; Age; Allergens; Allergies; allergy; antenatal; Antibodies - immunology; Arachis - adverse effects; Arachis - immunology; Arachis hypogaea; Asthma; Biological and medical sciences; Birth; Carbohydrates; Consumption; cross reacting carbohydrate determinants; Cross Reactions - immunology; Eating; Epitopes; Female; Follow-Up Studies; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Genetic crosses; Genetic factors; Humans; Hypersensitivity; Immunoglobulin E; Immunoglobulin E - immunology; Infants; Longitudinal Studies; Male; Maternal Exposure - adverse effects; Nuts; peanut; Peanut Hypersensitivity - epidemiology; Peanut Hypersensitivity - etiology; Peanut Hypersensitivity - immunology; Peanuts; Pregnancy; Prenatal Exposure Delayed Effects - chemically induced; Prenatal Exposure Delayed Effects - etiology; Prenatal Exposure Delayed Effects - immunology; rye grass; Secale - adverse effects; Secale - immunology; sensitization; Wheat Hypersensitivity - epidemiology; Wheat Hypersensitivity - etiology; Wheat Hypersensitivity - immunology; Human; Consumption; Immunopathology; Allergy; Peanut; Determinant; rye grass; Prenatal; Progeny; Immunology; Mother; Adolescent; Cross reaction; cross reacting carbohydrate determinants; adolescence; antenatal; Carbohydrate; Sensitization; Groundnut; Rye
• ISSN: 0954-7894; 1365-2222; 1365-2222
• DOI: 10.1111/j.1365-2222.2010.03668.x

Cite this as: A. S. Kemp, A‐L Ponsonby,T. Dwyer J. A. Cochrane, A. Pezic and G. Jones, Clinical & Experimental Allergy, 2011 (41) 224–231. Summary Background There is considerable controversy whether maternal peanut ingestion during pregnancy might influence sensitization in later life. Objective To examine whether maternal peanut ingestion during pregnancy might increase sensitization in the offspring. Methods A population‐based longitudinal cohort study with 16 years follow‐up was conducted (N=373). Subjects were recruited at birth as part of an infant health study. Maternal antenatal peanut consumption was documented at birth and peanut and rye sensitization were determined by measurement of serum‐specific IgE at age 16. Results Peanut sensitization was common (14%). In the entire cohort (n=310), there was no association between antenatal peanut ingestion and peanut sensitization (P=0.17). However, there was a strong association between antenatal peanut ingestion and decreased risk of rye sensitization and peanut sensitization in those (n=201) without a family history (FH) of asthma (Rye OR 0.30, 95% CI 0.14–0.63, P=0.001 and Peanut OR 0.18, 95% CI 0.04–0.78, P=0.02). There was an increased risk of rye sensitization in those (n=108) with a FH of asthma and antenatal peanut ingestion (Rye OR 2.69, 95% CI 1.11–6.51 P=0.03). It was considered that these sensitizations were likely to be related to the presence of IgE antibodies to cross‐reacting carbohydrate epitopes common to rye and peanut allergens. Conclusions and Clinical Relevance Antenatal peanut ingestion may influence the development of IgE antibody to cross‐reacting carbohydrate epitopes in later life. Genetic factors may modify this association.