Histologic and mammographic specificity of risk factors for benign breast disease

This study evaluates the effects of potential risk factors for benign breast disease (BBD) with special attention to the histologic and mammographic specificity of the effects. Cases were 172 women with BBD that underwent biopsy; controls were 134 women free of breast signs or symptoms. All cases an...

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Bibliographic Details
Published inCancer Vol. 64; no. 3; pp. 653 - 657
Main Authors Bright, Roselie A., Morrison, Alan S., Brisson, Jacques, Burstein, Nelson A., Sadowsky, Norman L., Kopans, Daniel B., Meyer, Jack E.
Format Journal Article
LanguageEnglish
Published New York Wiley Subscription Services, Inc., A Wiley Company 01.08.1989
Wiley-Liss
Subjects
Biological and medical sciences
Breast Diseases - diagnosis
Breast Diseases - etiology
Breast Diseases - pathology
Contraceptives, Oral - administration & dosage
Epidemiologic Methods
Estrogens - administration & dosage
Female
Gynecology. Andrology. Obstetrics
Humans
Hyperplasia - pathology
Mammary gland diseases
Mammography
Medical sciences
Menopause
Obesity
Parity
Risk Factors
Tumors
Human
Pathology
Mammary gland diseases
Radiodiagnosis
Risk factor
Mammography
Mammary gland
Benign neoplasm
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Summary:This study evaluates the effects of potential risk factors for benign breast disease (BBD) with special attention to the histologic and mammographic specificity of the effects. Cases were 172 women with BBD that underwent biopsy; controls were 134 women free of breast signs or symptoms. All cases and controls had undergone mammography. For all types of BBD combined, parity, use of oral contraceptives, and use of exogenous estrogen after menopause were strongly protective, whereas obesity and early menarche were weakly protective. Family history of breast cancer was virtually unrelated to BBD. The protective effect of parity was stronger for BBD with intralobular or extralobular fibrosis, and with mammographic homogeneous density or large nodular densities, than it was for BBD without these characteristics. Similar relations with the histologic and mammographic features were observed for obesity. These findings suggest that some risk factors for BBD have effects that are related to specific features of its morphology.
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ISSN:0008-543X
1097-0142
DOI:10.1002/1097-0142(19890801)64:3<653::AID-CNCR2820640315>3.0.CO;2-O