The role of type 2 innate lymphoid cells in asthma

Review of how innate lymphoid cells (newly described cell types that produce a variety of cytokines) appear to play important roles in asthma. Asthma is a complex and heterogeneous disease with several phenotypes, including an allergic asthma phenotype, characterized by Th2 cytokine production and a...

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Published inJournal of leukocyte biology Vol. 94; no. 5; pp. 933 - 940
Main Authors Chang, Ya‐Jen, DeKruyff, Rosemarie H., Umetsu, Dale T.
Format Journal Article
LanguageEnglish
Published United States Society for Leukocyte Biology 01.11.2013
Subjects
airway hyper‐reactivity
Allergens - immunology
allergy
Animals
Asthma - immunology
Asthma - therapy
Bacterial Infections - immunology
Humans
Immunity, Innate
influenza
Influenza, Human - immunology
Interleukin-13 - biosynthesis
Lung - immunology
Lymphocytes - immunology
NKT cells
Receptors, Interleukin - physiology
influenza
allergy
NKT cells
airway hyper-reactivity
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Summary:Review of how innate lymphoid cells (newly described cell types that produce a variety of cytokines) appear to play important roles in asthma. Asthma is a complex and heterogeneous disease with several phenotypes, including an allergic asthma phenotype, characterized by Th2 cytokine production and associated with allergen sensitization and adaptive immunity. Asthma also includes nonallergic asthma phenotypes that require innate rather than adaptive immunity. These innate pathways to asthma involve macrophages, neutrophils, as well as ILCs, newly described cell types that produce a variety of cytokines, including IL‐5 and IL‐13. We review the recent data regarding ILCs and their role in asthma.
Bibliography:ObjectType-Article-2
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ISSN:0741-5400
1938-3673
DOI:10.1189/jlb.0313127