Paradigms and progress in vocal fold restoration

Science advances occur through orderly steps, puzzle-solving leaps, or divergences from the accepted disciplinary matrix that occasionally result in a revolutionary paradigm shift. Key advances must overcome bias, criticism, and rejection. Examples in biological science include use of embryonic stem...

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Bibliographic Details
Published inThe Laryngoscope Vol. 118; no. 9; p. 1709
Main Author Ford, Charles N
Format Journal Article
LanguageEnglish
Published United States 01.09.2008
Subjects
Humans
Recovery of Function
Tissue Engineering - methods
Treatment Outcome
Vocal Cords - physiology
Voice Disorders - therapy
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Summary:Science advances occur through orderly steps, puzzle-solving leaps, or divergences from the accepted disciplinary matrix that occasionally result in a revolutionary paradigm shift. Key advances must overcome bias, criticism, and rejection. Examples in biological science include use of embryonic stem cells, recognition of Helicobacter pylori in the etiology of ulcer disease, and the evolution of species. Our work in vocal fold restoration reflects these patterns. We progressed through phases of tissue replacement with fillers and biological implants, to current efforts at vocal fold regeneration through tissue engineering, and face challenges of a new "systems biology" paradigm embracing genomics and proteomics.
ISSN:1531-4995
DOI:10.1097/mlg.0b013e31817c03c3