Virus-Associated Nephropathies: A Narrative Review

While most viral infections cause mild symptoms and a spontaneous favorable resolution, some can lead to severe or protracted manifestations, specifically in immunocompromised hosts. Kidney injuries related to viral infections may have multiple causes related to the infection severity, drug toxicity...

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Published inInternational journal of molecular sciences Vol. 23; no. 19; p. 12014
Main Authors Masset, Christophe, Le Turnier, Paul, Bressollette-Bodin, Céline, Renaudin, Karine, Raffi, François, Dantal, Jacques
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 10.10.2022
MDPI
Subjects
Acquired immune deficiency syndrome
acute kidney injury
AIDS
Apoptosis
Asymptomatic
Bacterial infections
Cell growth
Drug therapy
Epidemiology
glomerulopathy
Heparan sulfate
Hepatitis A
Hepatitis B
Hepatitis C
HIV
Human immunodeficiency virus
Immune response
Immune system
Immunocompromised hosts
Immunosuppression
Infections
Injuries
Kidney diseases
Kidney transplants
Kidneys
Life Sciences
Nephropathy
Review
Toxicity
viral infection
Viral infections
Viruses
nephropathy
acute kidney injury
viral infection
glomerulopathy
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Summary:While most viral infections cause mild symptoms and a spontaneous favorable resolution, some can lead to severe or protracted manifestations, specifically in immunocompromised hosts. Kidney injuries related to viral infections may have multiple causes related to the infection severity, drug toxicity or direct or indirect viral-associated nephropathy. We review here the described virus-associated nephropathies in order to guide diagnosis strategies and treatments in cases of acute kidney injury (AKI) occurring concomitantly with a viral infection. The occurrence of virus-associated nephropathy depends on multiple factors: the local epidemiology of the virus, its ability to infect renal cells and the patient’s underlying immune response, which varies with the state of immunosuppression. Clear comprehension of pathophysiological mechanisms associated with a summary of described direct and indirect injuries should help physicians to diagnose and treat viral associated nephropathies.
Bibliography:ObjectType-Article-2
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PMCID: PMC9569621
These authors contributed equally to this work.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms231912014