Cellular enlargement - A new hallmark of aging?
Years of important research has revealed that cells heavily invest in regulating their size. Nevertheless, it has remained unclear why accurate size control is so important. Our recent study using hematopoietic stem cells (HSCs) in vivo indicates that cellular enlargement is causally associated with...
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Published in | Frontiers in cell and developmental biology Vol. 10; p. 1036602 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Frontiers Media S.A
10.11.2022
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Subjects | |
Online Access | Get full text |
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Summary: | Years of important research has revealed that cells heavily invest in regulating their size. Nevertheless, it has remained unclear why accurate size control is so important. Our recent study using hematopoietic stem cells (HSCs)
in vivo
indicates that cellular enlargement is causally associated with aging. Here, we present an overview of these findings and their implications. Furthermore, we performed a broad literature analysis to evaluate the potential of cellular enlargement as a new aging hallmark and to examine its connection to previously described aging hallmarks. Finally, we highlight interesting work presenting a correlation between cell size and age-related diseases. Taken together, we found mounting evidence linking cellular enlargement to aging and age-related diseases. Therefore, we encourage researchers from seemingly unrelated areas to take a fresh look at their data from the perspective of cell size. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 Robert Antonius Maria De Bruin, University College London, United Kingdom This article was submitted to Cell Growth and Division, a section of the journal Frontiers in Cell and Developmental Biology Edited by: Jan M. Skotheim, Stanford University, United States Gabriel Neurohr, ETH Zürich, Switzerland Reviewed by: Akshay Narkar, United States Food and Drug Administration, United States |
ISSN: | 2296-634X 2296-634X |
DOI: | 10.3389/fcell.2022.1036602 |