Reversible Conduction Failure in Anti-lactosylceramide-antibody-positive Combined Central and Peripheral Demyelination
We describe a 60-year-old woman with combined central and peripheral demyelination who presented with obstinate constipation, weakness in the lower limbs, and a bilateral sensory disturbance below her chest followed by girdle sensation in the right region of the abdomen, which was responsive to ster...
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Published in | Frontiers in neurology Vol. 10; p. 600 |
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Main Authors | , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Switzerland
Frontiers Media S.A
07.06.2019
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Subjects | |
Online Access | Get full text |
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Summary: | We describe a 60-year-old woman with combined central and peripheral demyelination who presented with obstinate constipation, weakness in the lower limbs, and a bilateral sensory disturbance below her chest followed by girdle sensation in the right region of the abdomen, which was responsive to steroid therapy and plasmapheresis. Serum anti-lactosylceramide antibody was positive without anti-neurofascin 155 antibody or anti-galactocerebroside antibody positivity. Two months later, the patient had a first relapse that was responsive to steroid treatment. A nerve conduction study confirmed reversible conduction failure (RCF) in both episodes. Our case is unique in that she had an RCF episode as well as some similarities to encephalomyeloradiculoneuropathy. |
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Bibliography: | This article was submitted to Multiple Sclerosis and Neuroimmunology, a section of the journal Frontiers in Neurology Reviewed by: Ricardo Constantino Ginestal, Hospital Clínico San Carlos, Spain; Jun-ichi Kira, Kyushu University, Japan Edited by: Jorge Matias-Guiu, Complutense University of Madrid, Spain |
ISSN: | 1664-2295 1664-2295 |
DOI: | 10.3389/fneur.2019.00600 |