Reversible Conduction Failure in Anti-lactosylceramide-antibody-positive Combined Central and Peripheral Demyelination

• Published in: Frontiers in neurology Vol. 10; p. 600
• Main Authors: Harada, Masaya, Miura, Shiroh, Kida, Hiroshi, Moritaka, Taiga, Irie, Ken-Ichi, Kamada, Takashi, Uchiyama, Yusuke, Shima, Sayuri, Mutoh, Tatsuro, Hoshino, Tomoaki, Taniwaki, Takayuki
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 07.06.2019
• Subjects: combined central and peripheral demyelination (CCPD); encephalomyeloradiculoneuropathy (EMRN); lactosylceramide; Neurology; reversible conduction failure (RCF); steroid; total plasma exchange; therapy; reversible conduction failure (RCF); total plasma exchange; combined central and peripheral demyelination (CCPD); lactosylceramide; encephalomyeloradiculoneuropathy (EMRN); steroid
• ISSN: 1664-2295; 1664-2295
• DOI: 10.3389/fneur.2019.00600

We describe a 60-year-old woman with combined central and peripheral demyelination who presented with obstinate constipation, weakness in the lower limbs, and a bilateral sensory disturbance below her chest followed by girdle sensation in the right region of the abdomen, which was responsive to steroid therapy and plasmapheresis. Serum anti-lactosylceramide antibody was positive without anti-neurofascin 155 antibody or anti-galactocerebroside antibody positivity. Two months later, the patient had a first relapse that was responsive to steroid treatment. A nerve conduction study confirmed reversible conduction failure (RCF) in both episodes. Our case is unique in that she had an RCF episode as well as some similarities to encephalomyeloradiculoneuropathy.