Resting-state synchrony between anterior cingulate cortex and precuneus relates to body shape concern in anorexia nervosa and bulimia nervosa

• Published in: Psychiatry research. Neuroimaging Vol. 221; no. 1; pp. 43 - 48
• Main Authors: Lee, Seojung, Ran Kim, Kyung, Ku, Jeonghun, Lee, Jung-Hyun, Namkoong, Kee, Jung, Young-Chul
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 30.01.2014; Elsevier
• Subjects: Adult; Adult and adolescent clinical studies; Anorexia nervosa; Anorexia Nervosa - physiopathology; Anorexia Nervosa - psychology; Biological and medical sciences; Body Image; Body shape; Brain Mapping; Bulimia; Bulimia nervosa; Bulimia Nervosa - physiopathology; Bulimia Nervosa - psychology; Case-Control Studies; Cerebral Cortex - physiopathology; Eating behavior disorders; Electroencephalography Phase Synchronization; Female; Food; Functional Neuroimaging; Gyrus Cinguli - physiopathology; Humans; Magnetic Resonance Imaging; Medical sciences; Neural Pathways - physiopathology; Precuneus; Psychiatry; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Radiology; Resting state functional connectivity; Socioeconomic Factors; Body shape; Precuneus; Anorexia nervosa; Resting state functional connectivity; Bulimia nervosa; Human; Functional connectivity; Body image; Central nervous system; Eating disorder; Encephalon; Bulimia; Rest; Cingulate cortex; Parietal cortex; Parietal lobe
• ISSN: 0925-4927; 1872-7506
• DOI: 10.1016/j.pscychresns.2013.11.004

Abstract Cortical areas supporting cognitive control and salience demonstrate different neural responses to visual food cues in patients with eating disorders. This top-down cognitive control, which interacts with bottom-up appetitive responses, is tightly integrated not only in task conditions but also in the resting-state. The dorsal anterior cingulate cortex (dACC) is a key node of a large-scale network that is involved in self-referential processing and cognitive control. We investigated resting-state functional connectivity of the dACC and hypothesized that altered connectivity would be demonstrated in cortical midline structures involved in self-referential processing and cognitive control. Seed-based resting-state functional connectivity was analyzed in women with anorexia nervosa ( N =18), women with bulimia nervosa ( N =20) and age matched healthy controls ( N =20). Between group comparisons revealed that the anorexia nervosa group exhibited stronger synchronous activity between the dACC and retrosplenial cortex, whereas the bulimia nervosa group showed stronger synchronous activity between the dACC and medial orbitofrontal cortex. Both groups demonstrated stronger synchronous activity between the dACC and precuneus, which correlated with higher scores of the Body Shape Questionnaire. The dACC-precuneus resting-state synchrony might be associated with the disorder-specific rumination on eating, weight and body shape in patients with eating disorders.