Biocompatibility of sol-gel hydroxyapatite-titania composite and bilayer coatings

• Published in: Materials Science & Engineering C Vol. 72; pp. 650 - 658
• Main Authors: Sidane, D., Rammal, H., Beljebbar, A., Gangloff, S.C., Chicot, D., Velard, F., Khireddine, H., Montagne, A., Kerdjoudj, H.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.03.2017; Elsevier BV; Elsevier
• Subjects: Austenitic stainless steels; Biochemistry; Biocompatibility; Biological activity; Biological analysis; Biomedical materials; Cell Adhesion - drug effects; Cell Proliferation - drug effects; Cells, Cultured; Coated Materials, Biocompatible - chemistry; Coated Materials, Biocompatible - pharmacology; Coatings; Corrosion; Corrosion resistance; Corrosion resistant steels; Cytoskeleton - drug effects; Dip coatings; Durapatite - chemistry; Electrochemical Techniques; Engineering Sciences; Failure analysis; Gels - chemistry; Hardness; Heat resistant steels; Human behavior; Humans; Hydroxyapatite; Immersion coating; Materials science; Mechanical properties; Microscopy, Electron, Scanning; Modulus of elasticity; Protective coatings; Sol gel process; Sol-gel processes; Spectrometry, X-Ray Emission; Stability; Stability analysis; Stainless steel; Stainless Steel - chemistry; Stainless steel 316L; Stem cells; Stem Cells - cytology; Stem Cells - drug effects; Stem Cells - metabolism; Surface coating; Titania; Titanium - chemistry; Titanium dioxide; Umbilical Cord - cytology; X-Ray Diffraction; Biocompatibility; Hydroxyapatite; Stainless steel 316L; Titania; Surface coating; Stem cells
• ISSN: 0928-4931; 1873-0191
• DOI: 10.1016/j.msec.2016.11.129

Titania-Hydroxyapatite (TiO2/HAP) reinforced coatings are proposed to enhance the bioactivity and corrosion resistance of 316L stainless steel (316L SS). Herein, spin- and dip-coating sol-gel processes were investigated to construct two kinds of coatings: TiO2/HAP composite and TiO2/HAP bilayer. Physicochemical characterization highlighted the bioactivity response of the TiO2/HAP composite once incubated in physiological conditions for 7days whereas the TiO2/HAP bilayer showed instability and dissolution. Biological analysis revealed a failure in human stem cells adhesion on TiO2/HAP bilayer whereas on TiO2/HAP composite the presence of polygonal shaped cells, possessing good behaviour attested a good biocompatibility of the composite coating. Finally, TiO2/HAP composite with hardness up to 0.6GPa and elastic modulus up to 18GPa, showed an increased corrosion resistance of 316L SS. In conclusion, the user-friendly sol-gel processes led to bioactive TiO2/HAP composite buildup suitable for biomedical applications. •316L SS implant TiO2 reinforced HAP coatings were investigated and compared.•TiO2/HAP composite had better structural features and biocompatible properties.•Improvement of 316L SS implants corrosion resistance.•TiO2/HAP composite mechanical properties close to bone tissue•Low cost and desired material for hard tissue applications