From mice to men: Murine models of colorectal cancer for use in translational research

Abstract Colorectal cancer (CRC) is the third most common carcinoma worldwide and despite advances in treatment, survival for patients with metastatic disease remains poor. With nearly 50% of patients developing metastases, in vivo investigation is essential to improve outcomes for these patients an...

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Bibliographic Details
Published inCritical reviews in oncology/hematology Vol. 98; pp. 94 - 105
Main Authors Evans, Jonathan P, Sutton, Paul A, Winiarski, Boleslaw K, Fenwick, Stephen W, Malik, Hassan Z, Vimalachandran, Dale, Tweedle, Elizabeth M, Costello, Eithne, Palmer, Daniel H, Park, B. Kevin, Kitteringham, Neil R
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier Ireland Ltd 01.02.2016
Subjects
Animals
Colorectal cancer
Colorectal Neoplasms - chemically induced
Colorectal Neoplasms - etiology
Colorectal Neoplasms - genetics
Colorectal Neoplasms - pathology
Disease Models, Animal
Hematology, Oncology and Palliative Medicine
Humans
Male
Metastases
Mice
Murine models
Neoplasm Transplantation
Preclinical studies
Small animal imaging
Translational Research, Biomedical
Preclinical studies
Small animal imaging
Murine models
Colorectal cancer
Metastases
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Summary:Abstract Colorectal cancer (CRC) is the third most common carcinoma worldwide and despite advances in treatment, survival for patients with metastatic disease remains poor. With nearly 50% of patients developing metastases, in vivo investigation is essential to improve outcomes for these patients and numerous murine models of CRC have been developed to allow the study of chemoprevention and chemotherapy, in addition to improving our understanding of the pathogenesis of CRC. Selecting the most appropriate murine model for a specific application will maximize the conversion of potential therapies from the laboratory to clinical practice and requires an understanding of the various models available. This review will provide an overview of the murine models currently used in CRC research, discussing the limitations and merits of each and their most relevant application. It is aimed at the developing researcher, acting as a guide to prompt further reading in planning a specific study.
ISSN:1040-8428
1879-0461
DOI:10.1016/j.critrevonc.2015.10.009