Pathological clavicular fracture as first presentation of renal cell carcinoma： a case report and literature review

• Published in: Cancer biology & medicine Vol. 12; no. 4; pp. 409 - 412
• Main Authors: Kong, Yan, Wang, Jin, Li, Huan, Guo, Peng, Xu, Jian-Fa, Feng, He-Lin
• Format: Journal Article
• Language: English
• Published: China Chinese Anti-Cancer Association (CACA), Cancer Biology & Medicine 01.12.2015; Chinese Anti-Cancer Association; China Anti-Cancer Association
• Subjects: Bone surgery; Bones; Case Report; Clavicle; Clear cell-type renal cell carcinoma; Conflicts of interest; Fractures; Histopathology; Literature reviews; Liver; Liver cancer; Magnetic resonance imaging; Medical imaging; Melanoma; Metastases; Metastasis; NMR; Nuclear magnetic resonance; Pain; pathological fracture; Patients; Prostate; renal cell carcinoma (RCC); Scintigraphy; Skin cancer; Technetium; Thyroid gland; Trauma; Tumors; 农村信用社; 图像显示; 复习; 文献; 病理性; 癌; 肾细胞; 骨折; Saskatchewan Canada; East Asia; Oklahoma; Clavicle; metastasis; pathological fracture; renal cell carcinoma (RCC)
• ISSN: 2095-3941; 2095-3941
• DOI: 10.7497/j.issn.2095-3941.2015.0033

Renal cell carcinoma（RCC） accounts for approximately 3% of all cancer cases. RCCs usually metastasize to the lungs, bones, liver, or brain. Only 〈1% of patients with bone metastases manifested clavicular RCC metastases. Thus, clavicular metastasis as the initial presentation of RCC is extremely rare. We report a patient with RCC metastasis to the left clavicle, which was first presented with pain caused by a pathological fracture. Magnetic resonance image revealed a renal tumor, and technetium-99m-methylene diphosphonate bone scintigraphy showed multiple osseous metastases. The patient eventually underwent surgery to remove the lateral end of the left clavicle and right kidney. Histopathology revealed renal tumor and clear cell carcinoma in the clavicle. Finally, we review 17 cases of clavicular metastases originating from different malignancies.