Exercise is the real polypill

The concept of a "polypill" is receiving growing attention to prevent cardiovascular disease. Yet similar if not overall higher benefits are achievable with regular exercise, a drug-free intervention for which our genome has been haped over evolution. Compared with drugs, exercise is avail...

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Bibliographic Details
Published inPhysiology (Bethesda, Md.) Vol. 28; no. 5; pp. 330 - 358
Main Authors Fiuza-Luces, Carmen, Garatachea, Nuria, Berger, Nathan A, Lucia, Alejandro
Format Journal Article
LanguageEnglish
Published United States 01.09.2013
Subjects
Age Factors
Aging
Animals
Cardiovascular Diseases - epidemiology
Cardiovascular Diseases - metabolism
Cardiovascular Diseases - prevention & control
Drug Combinations
Exercise
Humans
Muscle, Skeletal - metabolism
Oxidative Stress
Physical Fitness
Polypharmacy
Risk Factors
Risk Reduction Behavior
Sedentary Lifestyle
Signal Transduction
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Summary:The concept of a "polypill" is receiving growing attention to prevent cardiovascular disease. Yet similar if not overall higher benefits are achievable with regular exercise, a drug-free intervention for which our genome has been haped over evolution. Compared with drugs, exercise is available at low cost and relatively free of adverse effects. We summarize epidemiological evidence on the preventive/therapeutic benefits of exercise and on the main biological mediators involved.
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ISSN:1548-9213
1548-9221
DOI:10.1152/physiol.00019.2013