Variable frequency stimulation of subthalamic nucleus in Parkinson's disease: Rationale and hypothesis

Highlights • Movement disorders are related with abnormal oscillations at different frequencies. • Frequency is an important characteristic in brain stimulation therapies. • High frequency stimulation only benefits certain motor symptoms in Parkinson's disease, while low frequency stimulation p...

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Published inParkinsonism & related disorders Vol. 39; pp. 27 - 30
Main Authors Jia, Fumin, Ph.D, Hu, Wei, M.D. Ph.D, Zhang, Jianguo, M.D. Ph.D, Shukla, Aparna Wagle, M.D, Almeida, Leonardo, M.D, Meng, Fan-gang, M.D. Ph.D, Okun, Michael S., M.D, Li, Luming, Ph.D
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.06.2017
Subjects
Biophysics
Deep brain stimulation
Deep Brain Stimulation - methods
Freezing of gait
Humans
Neurology
Parkinson Disease - therapy
Parkinson's disease
Subthalamic Nucleus - physiology
Variable frequency stimulation
Freezing of gait
Variable frequency stimulation
Parkinson's disease
Deep brain stimulation
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Summary:Highlights • Movement disorders are related with abnormal oscillations at different frequencies. • Frequency is an important characteristic in brain stimulation therapies. • High frequency stimulation only benefits certain motor symptoms in Parkinson's disease, while low frequency stimulation provides other selective symptomatic benefit. • Unlike a traditional fixed frequency stimulation method, a new pattern of variable frequency stimulation is proposed.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1353-8020
1873-5126
DOI:10.1016/j.parkreldis.2017.03.015