Lack of association between the G+2044A polymorphism of interleukin-13 gene and chronic obstructive pulmonary disease: a meta-analysis

• Published in: Molecular biology reports Vol. 41; no. 9; pp. 6297 - 6303
• Main Authors: Duan, Lian, Liang, Rui, Wang, Zhendong, Lei, Lei, Jin, Lianhong, Shen, Jingling, Jin, Shoude
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer-Verlag 01.09.2014; Springer Netherlands; Springer Nature B.V
• Subjects: Alleles; Animal Anatomy; Animal Biochemistry; Biomedical and Life Sciences; Chronic obstructive pulmonary disease; experimental design; Genes; Genetic Association Studies; Genetic Predisposition to Disease; genotype; genotyping; Histology; Humans; interleukin-13; Interleukin-13 - genetics; Life Sciences; Meta-analysis; Morphology; patients; Polymorphism; Polymorphism, Single Nucleotide; Pulmonary Disease, Chronic Obstructive - genetics; Risk Factors; Th2 Cells; 13; Chronic obstructive pulmonary disease; Association; G+2044A; Polymorphism
• ISSN: 0301-4851; 1573-4978; 1573-4978
• DOI: 10.1007/s11033-014-3512-z

Numerous studies have investigated association of interleukin-13 (IL-13) G+2044A polymorphism with COPD susceptibility; however, the results were inconsistent and inconclusive. To evaluate the association between the IL-13 G+2044A polymorphism and susceptibility to COPD, a meta-analysis of published case–control studies was performed. Based on PubMed and Chinese database, this research selected studies that examined the association of the IL-13 G+2044A polymorphism with COPD. A genetic model-free approach was used to assess whether the combined data showed this association. Then a subgroup analysis was also performed, with stratifications for race, study design, and sample size. Six studies (total 1,213 COPD patients and 801 control subjects) for the IL-13 G+2044A polymorphism with COPD were included in the meta-analysis (G- vs A-allele: OR 1.12, 95 % CI 0.96–1.32, P = 0.15; genotypes GG+GA vs genotype AA: OR 0.99, 95 % CI 0.49–2.00, P = 0.98; genotype GG vs genotypes GA+AA: OR 1.18, 95 % CI 0.97–1.44, P = 0.09; genotype GA vs genotypes GG+AA: OR 0.85, 95 % CI 0.70–1.04, P = 0.11). This meta-analysis demonstrates that the IL-13 G+2044A polymorphism does not confer susceptibility to COPD. More detailed data about individual and environment, larger sample sizes with unbiased genotyping methods and matched controls in different populations are required.