A tarantula peptide against pain via ASIC1a channels and opioid mechanisms

Psalmotoxin 1, a peptide extracted from the South American tarantula Psalmopoeus cambridgei, has very potent analgesic properties against thermal, mechanical, chemical, inflammatory and neuropathic pain in rodents. It exerts its action by blocking acid-sensing ion channel 1a, and this blockade resul...

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Bibliographic Details
Published inNature neuroscience Vol. 10; no. 8; pp. 943 - 945
Main Authors Lazdunski, Michel, Mazzuca, Michel, Heurteaux, Catherine, Alloui, Abdelkrim, Diochot, Sylvie, Baron, Anne, Voilley, Nicolas, Blondeau, Nicolas, Escoubas, Pierre, Gélot, Agnès, Cupo, Anny, Zimmer, Andreas, Zimmer, Anne M, Eschalier, Alain
Format Journal Article
LanguageEnglish
Published United States Nature Publishing Group 01.08.2007
Subjects
Acid Sensing Ion Channels
Analgesics
Analgesics - therapeutic use
Animals
Araneae
Area Under Curve
Behavior, Animal
Care and treatment
Disease Models, Animal
Dosage and administration
Dose-Response Relationship, Drug
Enkephalins - deficiency
Enkephalins - physiology
Life Sciences
Membrane Proteins - deficiency
Membrane Proteins - physiology
Mice
Mice, Knockout
Morphine
Morphine - administration & dosage
Naloxone - administration & dosage
Naltrexone - administration & dosage
Narcotic Antagonists - administration & dosage
Narcotics
Nerve Tissue Proteins - deficiency
Nerve Tissue Proteins - physiology
Neurons - drug effects
Neurons - physiology
Neurons and Cognition
Pain
Pain - drug therapy
Pain Measurement - methods
Peptides
Pharmaceutical sciences
Physiological aspects
Protein Precursors - deficiency
Reaction Time - drug effects
Sodium Channels - deficiency
Sodium Channels - physiology
Spider Venoms - therapeutic use
Spinal Cord - pathology
Tarantulas
Time Factors
Germany
France
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Summary:Psalmotoxin 1, a peptide extracted from the South American tarantula Psalmopoeus cambridgei, has very potent analgesic properties against thermal, mechanical, chemical, inflammatory and neuropathic pain in rodents. It exerts its action by blocking acid-sensing ion channel 1a, and this blockade results in an activation of the endogenous enkephalin pathway. The analgesic properties of the peptide are suppressed by antagonists of the μ and δ-opioid receptors and are lost in Penk1−/− mice.
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ISSN:1097-6256
1546-1726
DOI:10.1038/nn1940