Phosphatidylinositol Synthase and Diacylglycerol Platforms Bust a Move

Kim et al. (2011) challenge the dogma that phosphatidylinositol synthesis is restricted to the endoplasmic reticulum (ER) by showing that a mobile membrane compartment transports phosphatidylinositol synthase from the ER to numerous cellular compartments, including the plasma membrane. These finding...

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Bibliographic Details
Published inDevelopmental cell Vol. 21; no. 5; pp. 810 - 812
Main Authors Bankaitis, Vytas A., Grabon, Aby
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 15.11.2011
Subjects
cell communication
endoplasmic reticulum
enzymes
myo-inositol
plasma membrane
synthesis
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Summary:Kim et al. (2011) challenge the dogma that phosphatidylinositol synthesis is restricted to the endoplasmic reticulum (ER) by showing that a mobile membrane compartment transports phosphatidylinositol synthase from the ER to numerous cellular compartments, including the plasma membrane. These findings significantly impact our view of phosphoinositide signaling in the cell.
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ISSN:1534-5807
1878-1551
1878-1551
DOI:10.1016/j.devcel.2011.10.016